GAL3ST3 Inhibitors
GAL3ST3 Inhibitors represent a chemical class of compounds designed to specifically target and modulate the activity of the enzyme GAL3ST3, or Galactose-3-O-sulfotransferase 3. GAL3ST3 is a vital enzyme involved in the sulfation of carbohydrates, particularly glycosaminoglycans (GAGs), within the extracellular matrix and cell surface. This enzymatic process is crucial for various cellular functions, including cell adhesion, signaling, and regulation of the extracellular matrix's structural integrity. GAL3ST3 inhibitors work by disrupting this sulfation process, leading to the alteration of carbohydrate structures, which can ultimately impact cellular interactions, signaling pathways, and the physiological roles of GAGs in various biological contexts.
The mechanism of action of GAL3ST3 inhibitors typically involves competitive or non-competitive binding to the enzyme's active site. These inhibitors can interfere with the binding of the enzyme's natural substrate, 3'-phosphoadenosine-5'-phosphosulfate (PAPS), or directly inhibit the catalytic activity of GAL3ST3. By doing so, GAL3ST3 inhibitors hinder the transfer of sulfate groups from PAPS to carbohydrates, preventing the sulfation of GAGs. As a consequence, the altered carbohydrate structures fail to contribute to normal cell-matrix interactions and signaling events, affecting processes like cell adhesion and the regulation of cellular responses to growth factors and cytokines. This class of inhibitors plays a significant role in basic research to investigate the biological roles of GAGs and their impact on cellular behavior, particularly in processes related to cell adhesion, migration, and growth factor signaling. Their utility lies in their ability to provide researchers with precise tools to dissect and understand the complex biology of carbohydrate sulfation and its effects on cellular physiology.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin inhibits GAL3ST3 by competitively binding to its active site, preventing the enzyme from adding sulfate groups to carbohydrates. This disrupts the sulfation process essential for the formation of glycosaminoglycans (GAGs), interfering with cell-matrix interactions and signaling pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits GAL3ST3 by disrupting its enzymatic activity, thereby preventing the sulfation of carbohydrates. This inhibition interferes with glycosaminoglycan (GAG) synthesis and cellular processes dependent on GAGs. | ||||||
Diosgenin | 512-04-9 | sc-205652 sc-205652B sc-205652A | 5 g 25 g 100 g | $46.00 $128.00 $507.00 | 4 | |
Diosgenin inhibits GAL3ST3 by interfering with its catalytic function, leading to reduced sulfation of carbohydrates. This disrupts glycosaminoglycan (GAG) production, impacting various cellular processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein inhibits GAL3ST3 by blocking its active site, preventing the enzyme from sulfating carbohydrates. This disruption hampers glycosaminoglycan (GAG) formation and downstream cellular functions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin inhibits GAL3ST3 by interfering with its enzymatic activity, impeding the sulfation of carbohydrates. This disruption affects glycosaminoglycan (GAG) synthesis and related cellular processes. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine inhibits GAL3ST3 by binding to its active site, reducing the enzyme's sulfation activity on carbohydrates. This interruption disrupts glycosaminoglycan (GAG) formation and associated cellular functions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin inhibits GAL3ST3 by competitively binding to its active site, hindering carbohydrate sulfation. This interference disrupts glycosaminoglycan (GAG) synthesis and cellular processes relying on GAGs. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol inhibits GAL3ST3 by disrupting its enzymatic activity, preventing the sulfation of carbohydrates. This interference impacts glycosaminoglycan (GAG) production and related cellular functions. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $56.00 $71.00 $124.00 | 7 | |
Rutin inhibits GAL3ST3 by binding to its active site, impeding carbohydrate sulfation. This interference disrupts glycosaminoglycan (GAG) synthesis and associated cellular processes. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $95.00 $184.00 $255.00 $500.00 $1002.00 | 3 | |
Myricetin inhibits GAL3ST3 by competitively binding to its active site, inhibiting carbohydrate sulfation. This interference disrupts glycosaminoglycan (GAG) synthesis and related cellular functions. | ||||||