GAL3ST3 Activators

Galactose-3-O-sulfotransferase 3 (GAL3ST3) is an enzyme that plays a crucial role in the biological process of sulfation, specifically the sulfation of galactose-containing glycolipids and glycoproteins. This enzyme belongs to the family of galactose-3-O-sulfotransferases, which are involved in transferring a sulfate group to the 3rd position of galactose residues in complex molecules. The activity of GAL3ST3 is essential for the proper functioning of various biological systems, as sulfation significantly alters the properties of molecules, impacting their roles in cellular communication, signal transduction, and molecular recognition.

The sulfated products generated by GAL3ST3 are important in several physiological processes. They are involved in cell adhesion, blood coagulation, and the modulation of inflammatory responses. These sulfated glycoconjugates can also play roles in the development and maintenance of the nervous system and are implicated in various signaling pathways.The expression of GAL3ST3 is regulated by cellular and physiological factors, and its dysregulation can contribute to pathological conditions. For instance, aberrant sulfation patterns, due to altered GAL3ST3 activity, have been associated with disorders in cell signaling and have implications in diseases such as cancer, where cell communication and adhesion are key factors.