GAGE4 Activators
GAGE4, a protein with specific functional roles in cellular processes, can be activated through several biochemical pathways influenced by particular chemical activators. For instance, the elevation of intracellular cAMP by specific adenylyl cyclase activators can lead to the activation of protein kinase A (PKA), which may phosphorylate proteins including GAGE4, enhancing its activity. Similarly, analogs of diacylglycerol, which serve as activators of protein kinase C (PKC), can initiate a cascade of phosphorylation events that may culminate in the upregulation of GAGE4's functional activity. Furthermore, the introduction of calcium ionophores that increase intracellular calcium concentrations can indirectly activate calcium-dependent kinases, which are capable of targeting and potentially increasing the functional activity of GAGE4.
The modulation of cyclic nucleotide levels through the inhibition of phosphodiesterases provides another avenue for GAGE4 activation. By preventing the breakdown of cAMP, selective inhibitors can sustain the activation of PKA, potentially influencing the phosphorylation state of GAGE4. Additionally, the strategic inhibition of key enzymes in the PI3K/Akt and MAPK/ERK pathways can lead to alterations in the phosphorylation patterns of proteins that interact with or modify the activity of GAGE4. The inhibition of serine/threonine phosphatases also results in increased phosphorylation levels across a spectrum of proteins, which may contribute to the heightened activity of GAGE4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator that increases intracellular cAMP levels, leading to the activation of PKA. PKA can phosphorylate various proteins, potentially including GAGE4, resulting in increased activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Diacylglycerol analog that activates protein kinase C (PKC). PKC phosphorylation can lead to the activation of secondary signaling pathways that may enhance the activity of GAGE4. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Calcium ionophore that increases intracellular calcium levels, indirectly activating calcium-dependent kinases which may target and increase the functional activity of GAGE4. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore that also elevates intracellular calcium, possibly activating calcium/calmodulin-dependent protein kinases which could then enhance GAGE4 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, leading to increased cAMP levels and subsequent activation of PKA. This cascade can result in the phosphorylation and activation of proteins, potentially including GAGE4. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Selective inhibitor of phosphodiesterase 5 (PDE5), increasing cAMP and cGMP levels which may lead to the activation of downstream kinases that enhance GAGE4 activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Selective PDE4 inhibitor that prevents cAMP breakdown, potentially resulting in the activation of PKA and subsequent phosphorylation of proteins including GAGE4. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that indirectly modulates the Akt signaling pathway, potentially leading to altered phosphorylation states of proteins downstream, possibly including GAGE4. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibitor of MEK1/2, leading to modulation of the MAPK/ERK pathway, which might indirectly result in the activation of proteins that interact with or modify GAGE4 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor that may affect downstream signaling, potentially leading to the activation of proteins in pathways that include GAGE4. | ||||||