GAGE2D Activators
Certain compounds are known to influence the activation of GAGE2D through indirect pathways by modulating cellular signaling or gene expression. For instance, molecules that increase intracellular cyclic AMP (cAMP) levels can trigger a cascade of events, including the activation of protein kinase A (PKA), which may subsequently enhance the functional activity of GAGE2D. Similarly, analogs of diacylglycerol that stimulate protein kinase C (PKC) can initiate downstream signaling pathways that ultimately lead to an upregulation of GAGE2D's activity. Additionally, the inhibition of phosphodiesterases resulting in elevated cAMP and cyclic GMP (cGMP) could also potentially amplify GAGE2D function through these signaling mediators.
Moreover, certain chemicals capable of altering chromatin structure and epigenetic states, such as histone deacetylase inhibitors and DNA methyltransferase inhibitors, may increase the expression of GAGE2D by enhancing the accessibility of its genetic locus to transcriptional machinery. Cofactors involved in neurotransmitter synthesis and zinc ionophores might modulate various signaling pathways and transcription factors, thereby indirectly influencing GAGE2D activation. Polyphenolic compounds that interact with multiple cellular targets could also lead to transcriptional changes that favor GAGE2D activation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An adenylate cyclase activator, which increases cAMP levels. Elevated cAMP may enhance the activity of GAGE2D by cAMP-dependent protein kinase (PKA) signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diacylglycerol analog that activates protein kinase C (PKC). PKC activation might upregulate GAGE2D activity as part of downstream signaling cascades. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A nonspecific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels, potentially enhancing GAGE2D activity through these signaling molecules. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol that may influence epigenetic modifications, possibly leading to a chromatin state that facilitates GAGE2D activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A histone deacetylase inhibitor that can lead to an open chromatin structure, potentially increasing the accessibility of GAGE2D to transcriptional machinery. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of vitamin A that modulates gene expression through retinoid receptors, which may include genes like GAGE2D. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor, which could allow for greater GAGE2D expression through increased chromatin accessibility. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, which could demethylate the GAGE2D promoter region, potentially leading to its increased expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Can increase intracellular zinc levels, which may modulate various signaling pathways and transcription factors that could enhance GAGE2D activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound with various cellular targets that could affect transcription factor activity, potentially upregulating GAGE2D. | ||||||