GAGE12E Activators
GAGE12E activators are intricately involved in various cellular signaling pathways, exerting their influence by different biochemical mechanisms. Compounds that elevate intracellular cAMP levels act by activating adenylate cyclase, subsequently enhancing protein kinase A signaling. This elevation can lead to the phosphorylation of multiple target proteins, potentially including GAGE12E, thereby altering its functional state or the activity of proteins that interact with it. Similarly, inhibition of phosphodiesterases, which prevents cAMP breakdown, can potentiate PKA activity and hence could indirectly lead to the phosphorylation and subsequent activation of GAGE12E. Furthermore, certain activators target histone deacetylases, causing hyperacetylation of histones and possibly leading to increased transcription and subsequent higher levels of GAGE12E protein. Others act on different cellular kinases like PKC and calcium-dependent proteins, which can initiate downstream signaling events that may enhance the activity of GAGE12E through post-translational modifications or changes in protein-protein interactions.
Several activators involve the modulation of cellular stress and apoptosis pathways, including those influenced by polyphenols and other natural compounds. These compounds can indirectly lead to the activation of GAGE12E by altering redox-sensitive signaling pathways or modulating the activity of regulatory proteins. Inhibition of key signaling molecules such as PI3K or mTOR can also lead to compensatory cellular responses that may include the activation of GAGE12E as the cell attempts to restore signaling equilibrium. Additionally, activators that increase cGMP levels within cells can enhance cGMP-dependent signaling pathways, which might indirectly activate GAGE12E by influencing the regulatory proteins that modulate its activity or stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and thereby increase the activity of GAGE12E by altering its conformation or interaction with other proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which phosphorylates target proteins. Activation of PKC could lead to phosphorylation of GAGE12E, enhancing its protein-protein interactions and its functional activity within cellular processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels. The increase in calcium can activate calmodulin-dependent kinase (CaMK), which could then phosphorylate and activate GAGE12E, as it may be a substrate or interact with substrates of this kinase. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that elevates intracellular cAMP levels, leading to PKA activation. PKA may target GAGE12E directly or its associated signaling proteins for phosphorylation, thus enhancing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that activates PKA. PKA can phosphorylate GAGE12E, which could result in increased functional activity of GAGE12E through post-translational modification. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium, activating calcium-dependent proteins, potentially including CaMK, which may then phosphorylate GAGE12E, thereby increasing its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A. By inhibiting dephosphorylation, it can maintain the phosphorylated and activated state of proteins, potentially including GAGE12E if it is regulated by phosphorylation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 could lead to the activation of downstream signaling proteins, potentially affecting the phosphorylation state and activity of GAGE12E. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates transient receptor potential vanilloid 1 (TRPV1) channels, which can lead to calcium influx and activation of calcium-dependent signaling pathways. Such pathways may indirectly activate GAGE12E through calcium-sensitive kinases. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium fluoride is an activator of G-proteins, which can stimulate various downstream signaling cascades, such as the cAMP pathway. Activation of these pathways could lead to the phosphorylation and activation of GAGE12E through kinase cascades. | ||||||