GAGE12C Activators
GAGE12C activators encompass a diverse set of chemical compounds that indirectly promote the protein's functional activity through various biochemical pathways and epigenetic modifications. Some activators function by enhancing intracellular signaling cascades implicated in cell proliferation and survival, which could lead to the upregulation of GAGE12C expression in cancer cells. These compounds increase levels of second messengers like cyclic AMP, triggering a cascade of downstream events, including the activation of protein kinase A. Subsequently, this kinase phosphorylates specific transcription factors that can bind to promoter regions of genes like GAGE12C, enhancing their transcription. Other activators operate via modulation of calcium ion concentrations within cells, impacting numerous signaling pathways and potentially influencing the expression of genes involved in cellular growth and immune evasion, including GAGE12C.
Moreover, certain molecules are known to act on the epigenetic landscape of cells, removing repressive marks on the DNA and histones associated with genes like GAGE12C. By inhibiting enzymes responsible for DNA methylation or histone deacetylation, these compounds can trigger the unwinding of tightly packed chromatin and facilitate the transcriptional activation of GAGE12C. The strategic use of these epigenetic modulators can therefore indirectly increase the expression of GAGE12C by enhancing the accessibility of its promoter to the transcriptional machinery, further contributing to the protein's activity within the cellular environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cyclic AMP (cAMP) levels. Elevated cAMP may enhance GAGE12C activity by promoting cell proliferation and survival signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in various signaling pathways that can lead to cellular proliferation and survival, processes potentially linked to GAGE12C activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Inhibits DNA methyltransferases, potentially leading to the demethylation and activation of genes like GAGE12C, which are typically silenced in normal tissues but active in cancers. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate sirtuins, which may influence chromatin remodeling and gene expression, possibly leading to the activation of GAGE12C in certain cancer cells. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, can alter chromatin structure and gene expression, possibly leading to the activation of normally silenced genes like GAGE12C. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can cause chromatin remodeling and activate gene expression, potentially including GAGE12C. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methyltransferase inhibitor that can lead to gene demethylation and reactivation of silenced genes, which may include GAGE12C in cancer cells. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit the proteasome, leading to the accumulation of proteins including potentially those like GAGE12C, involved in stress responses and survival pathways in cancer cells. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3, which can lead to the activation of Wnt signaling, a pathway that may upregulate proteins like GAGE12C involved in cell proliferation. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Acts as an L-type calcium channel agonist, which can increase intracellular calcium levels, potentially influencing pathways that activate genes like GAGE12C. | ||||||