GABP-β1 Inhibitors

The inhibitors listed target various aspects of mitochondrial function and cellular energy metabolism, processes in which GABP-β1 is potentially involved due to its role in regulating genes important for mitochondrial biogenesis and function. Metformin and Resveratrol influence AMPK and SIRT1, respectively, both of which are involved in regulating mitochondrial function and energy metabolism, potentially affecting GABP-β1's regulatory roles. Oligomycin, Antimycin A, Rotenone, and FCCP directly target different components of the mitochondrial electron transport chain, which could indirectly impact the mitochondrial functions regulated by GABP-β1.

MitoQ, as a mitochondria-targeted antioxidant, can influence mitochondrial health and thus potentially affect GABP-β1 activity. 2-Deoxy-D-glucose inhibits glycolysis, thereby potentially influencing the cellular energy state and indirectly affecting GABP-β1 function. Rapamycin, an mTOR inhibitor, affects protein synthesis and cell growth, processes that can impact mitochondrial function and thus potentially GABP-β1. Actinonin inhibits mitochondrial peptidases, affecting mitochondrial protein processing, which may influence GABP-β1-regulated pathways. Sodium azide and Nitric oxide donors impact mitochondrial respiration, potentially affecting processes regulated by GABP-β1.