GABP-β1/2 Antibody (E-1): sc-271531

GABP-β1/2 Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects GABP-β1/2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GABP-β1/2 (E-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GABP (GA-binding protein) transcription factor is crucial for regulating gene expression, composed of two subunits: the Ets-related GABP-α and GABP-β subunit, which has two splice variants, β1 and β2, differing in their C-termini. GABP-β presence in both cytoplasm and nucleus of primary neuronal cultures highlights a dual role in cellular processes, as GABP-α predominantly resides in the nucleus. This localization allows GABP to coordinate transcriptional regulation between nucleus and mitochondria, particularly for genes involved in energy metabolism and cellular growth. GABPαβ tetrameric complex stimulates transcription of various genes, including adenovirus E4 gene and BRCA1 in breast cell lines, while also playing a role in mitochondrial function and rpL32 gene transcription regulation. Anti-GABP-β1/2 antibody (E-1) serves as an essential tool for researchers studying transcriptional mechanisms and cellular signaling pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GABP-β1/2 Antibody (E-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GABP-β1/2 Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GABP-β1/2 Antibody (E-1) Specifications

Alternate Product Name: GABP-β1/2

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 131-395

Epitope Target: GABP-β1

Epitope Species: human

Product Reactivity/Detection: GABP-β1 and GABP-β2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GABP-β1/2 Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred GABP-β1/2 antibody is GABP-β1/2 Antibody (E-7): sc-271571.