FSD1L Activators
Forskolin enhances adenylate cyclase activity, leading to increased cAMP levels and subsequent activation of protein kinase A (PKA). PKA has the potential to phosphorylate FSD1L or regulate its activity indirectly. Ionomycin, by increasing intracellular calcium, can trigger calcium-dependent signaling pathways which may affect FSD1L function. Similarly, PMA activates protein kinase C (PKC), a kinase that phosphorylates numerous substrates and could modulate FSD1L activity either directly or indirectly. Epidermal growth factor (EGF) binds to its receptor to initiate signaling cascades that might influence FSD1L activity. Retinoic acid, by interacting with its nuclear receptors, can affect gene transcription, potentially altering FSD1L expression. Compounds like lithium chloride inhibit glycogen synthase kinase-3 (GSK-3), which may impact FSD1L activity if it is regulated by GSK-3 mediated pathways.
Dibutyryl-cAMP (db-cAMP), a synthetic analog of cAMP, directly activates PKA, suggesting another route by which FSD1L activity could be modulated. The epigenetic landscape also contributes to regulating FSD1L, where inhibitors like sodium butyrate can enhance gene expression by affecting histone acetylation, possibly including that of FSD1L. Adrenergic agonists such as isoproterenol increase intracellular cAMP and activate PKA, similar to forskolin, which may affect FSD1L activity. Dexamethasone bind to glucocorticoid receptors and can modulate gene expression, with potential effects on FSD1L. The inhibition of mTOR by rapamycin represents yet another mechanism that could indirectly influence FSD1L activity through mTOR's extensive signaling network. Resveratrol impact sirtuins and AMP-activated protein kinase (AMPK), both of which are involved in cellular stress responses and metabolic regulation, potentially affecting FSD1L activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin facilitates the release of intracellular calcium stores, thus activating calcium-dependent signaling pathways. If FSD1L activity is modulated by calcium signaling, ionomycin can augment its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC, which can phosphorylate numerous targets. If FSD1L is regulated by PKC or its downstream effectors, PMA can have a role in modulating its activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid binds nuclear receptors that regulate gene transcription. If FSD1L expression or activity is controlled by such receptors, this compound can influence FSD1L levels. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3, a kinase involved in numerous signaling pathways. If FSD1L is regulated by GSK-3 or its downstream effectors, inhibition by lithium chloride can lead to increased FSD1L activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
As a cAMP analog, db-cAMP can diffuse into cells and activate PKA. If FSD1L is affected by PKA signaling, db-cAMP can modulate its activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor, which leads to chromatin remodeling and can affect gene expression. If the FSD1L gene is epigenetically regulated, sodium butyrate can enhance its expression. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, as a beta-adrenergic agonist, increases intracellular cAMP, potentially activating PKA. If FSD1L is under the regulatory influence of PKA, isoproterenol can increase its activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone acts on glucocorticoid receptors affecting gene transcription. If FSD1L expression or activity is influenced by glucocorticoid signaling, dexamethasone can modulate its levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and metabolism. If FSD1L activity or expression is affected by mTOR signaling, rapamycin can impact its function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to modulate multiple signaling pathways, including sirtuins and AMPK. If FSD1L is regulated by these pathways or their downstream targets, resveratrol can modulate its activity. | ||||||