Date published: 2026-4-18

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FRP-1 Inhibitors

FRP-1 inhibitors, also known as Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Related Protein-1 inhibitors, represent a class of chemical compounds designed to target a specific cellular signaling pathway within the body. These inhibitors are primarily developed for their potential in understanding and modulating cell growth and differentiation processes, with applications in research and experimental contexts. FRP-1, or FRS2-related protein-1, is a critical protein involved in the fibroblast growth factor receptor (FGFR) signaling pathway, which plays a pivotal role in cellular proliferation, differentiation, and tissue development. Chemically, FRP-1 inhibitors are designed to interfere with the activation or function of FRP-1 within the FGFR signaling cascade. By doing so, they can influence downstream cellular responses and signaling events. Researchers and scientists employ FRP-1 inhibitors to elucidate the intricate molecular mechanisms underlying cell growth, differentiation, and various developmental processes. These compounds offer valuable tools for dissecting the roles of specific signaling pathways in both normal and pathological conditions.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Methotrexate

59-05-2sc-3507
sc-3507A
100 mg
500 mg
$94.00
$213.00
33
(5)

Methotrexate may inhibit FRP-1 expression by competing with folate, thereby reducing folate receptor availability and cellular uptake.

Raltitrexed

112887-68-0sc-219933
10 mg
$146.00
(0)

As a folate analog, raltitrexed could potentially downregulate FRP-1 expression by inhibiting the need for folate transport.

Pemetrexed Disodium

150399-23-8sc-219564
10 mg
$136.00
5
(1)

Pemetrexed functions as an antifolate drug and could decrease FRP-1 expression by reducing cellular folate levels.

Aminopterin

54-62-6sc-202461
50 mg
$102.00
1
(1)

Aminopterin acts similarly to methotrexate and may inhibit FRP-1 by competing with folate receptors.

Pyrimethamine

58-14-0sc-208190
sc-208190A
sc-208190B
1 g
5 g
25 g
$80.00
$238.00
$825.00
5
(0)

Pyrimethamine is known to inhibit dihydrofolate reductase, which may lead to a decreased requirement for folate transport via FRP-1.

Trimethoprim

738-70-5sc-203302
sc-203302A
sc-203302B
sc-203302C
sc-203302D
5 g
25 g
250 g
1 kg
5 kg
$67.00
$161.00
$255.00
$721.00
$3401.00
4
(1)

Trimethoprim inhibits bacterial dihydrofolate reductase, which indirectly may reduce the expression of FRP-1 in bacterial systems.

Triamterene

396-01-0sc-213103A
sc-213103
1 g
5 g
$22.00
$54.00
(0)

Triamterene may incidentally lower FRP-1 expression due to its interference with folate metabolism.

Sulfasalazine

599-79-1sc-204312
sc-204312A
sc-204312B
sc-204312C
1 g
2.5 g
5 g
10 g
$61.00
$77.00
$128.00
$209.00
8
(1)

Sulfasalazine can interfere with folate absorption and potentially downregulate FRP-1 as part of its mechanism.

Pyroxamide

382180-17-8sc-397030
5 mg
$79.00
(0)

Pyroxamide, a histone deacetylase inhibitor, may indirectly affect the expression of genes like FRP-1.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$37.00
$152.00
11
(1)

Fluorouracil is incorporated into RNA and DNA and can alter gene expression patterns, possibly including FRP-1.