Molecular structure of Aminopterin, CAS Number: 54-62-6
Aminopterin (CAS 54-62-6)
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Alternate Names:
4-Aminopteroylglutamic acid; 4-Aminofolic acid; 4-Amino-PGA
Application:
Aminopterin is a dihydrofolate reductase inhibitor and folic acid antagonist
CAS Number:
54-62-6
Purity:
≥98%
Molecular Weight:
440.40
Molecular Formula:
C19H20N8O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aminopterin is a folic acid antagonist. Potent DHFR (dihydrofolate reductase) inhibitor. Aminopterin, a synthetic molecule derived from folate pterin, acts as a folic acid antagonist and inhibits dihydrofolate reductase (DHFR). This compound is extensively employed in scientific research to explore gene expression, cell signaling pathways, and various biochemical and physiological processes. Its applications encompass studying the impact of gene expression on cell proliferation and differentiation, investigating the influence of cell signaling pathways on gene expression, and conducting drug screening assays to examine the effects of small molecules on gene expression and cell signaling pathways.
Aminopterin (CAS 54-62-6) References
- Further case of aminopterin syndrome sine aminopterin in a Spanish child. | Garcia-Minaur, S. and Botella, MP. 2000. Am J Med Genet. 95: 320-4. PMID: 11186884
- Aminopterin-human serum albumin conjugate (AP-HSA): uptake and cytotoxic effects in tumor cell lines. | Eschen, N., et al. 2002. Int J Clin Pharmacol Ther. 40: 564-6. PMID: 12503815
- Intrathecal aminopterin therapy of meningeal leukemia. | RIESELBACH, RE., et al. 1963. Arch Intern Med. 111: 620-30. PMID: 13973810
- Oral florid papillomatosis. Response to aminopterin. | SAMITZ, MH. and WEINBERG, RA. 1963. Arch Dermatol. 87: 478-80. PMID: 13991317
- On the mechanism of action of aminopterin. | NICHOL, CA. and WELCH, AD. 1950. Proc Soc Exp Biol Med. 74: 403-11. PMID: 15440837
- Aminopterin might be safe in ALL. | Burton, A. 2007. Lancet Oncol. 8: 873. PMID: 17974054
- Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias. | Norris, RE. and Adamson, PC. 2010. Cancer Chemother Pharmacol. 65: 1125-30. PMID: 19784838
- Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. | Uwai, Y. and Iwamoto, K. 2010. Drug Metab Pharmacokinet. 25: 163-9. PMID: 20460822
- Adenosine blocks aminopterin-induced suppression of osteoclast differentiation. | Teramachi, J., et al. 2013. J Bone Miner Metab. 31: 64-70. PMID: 23111587
- Enhanced polyglutamylation of aminopterin relative to methotrexate in the Ehrlich ascites tumor cell in vitro. | Matherly, LH., et al. 1985. Cancer Res. 45: 1073-8. PMID: 2578870
- Synthesis of analogues of folic acid, aminopterin and methotrexate as antitumour agents. | Palmer, DC., et al. 1988. Prog Med Chem. 25: 85-231. PMID: 3076971
- Effect of 'aminopterin' on epithelial tissues. | Gubner, R. 1983. Arch Dermatol. 119: 513-24. PMID: 6859892
- Aminopterin Syndrome Sine Aminopterin (ASSA) syndrome in two siblings: further delineation of the syndrome and review of the literature. | Krajewska-Walasek, M. 1994. Genet Couns. 5: 345-55. PMID: 7888136
Inhibitor of:
γ-FR, ALDH1L2, ALMS1, biotinidase, cSHMT, Cytokeratin 23, DHFR, DHFRL1, Dynlt1f, Enzyme, FAST, Folate, Folic Acid, FRP-1, Gγ 3, I830077J02Rik, Isoc2b, Jaz, LOC100039830, MFT, MMADHC, mSHMT, MSR, MTHFR, MTHFS, MTHFSD, MTR, PCBD2, PPC Synthetase, PROSC, RIMBP3C, sarcosine dehydrogenase, SPA-1, Su, THTPA, Trav12n-1, TS, and Vitrin.Activator of:
CtBP1, CTP, DHFR, DTYMK, HCP1, MTHFS, and PRPS1L1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aminopterin, 50 mg | sc-202461 | 50 mg | $102.00 |