Molecular structure of Pyrimethamine, CAS Number: 58-14-0
Pyrimethamine (CAS 58-14-0)
See product citations (5)
Alternate Names:
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; Daraprim
Application:
Pyrimethamine is an inhibitor of P-glycoprotein and DHFR
CAS Number:
58-14-0
Purity:
≥95%
Molecular Weight:
248.71
Molecular Formula:
C12H13ClN4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pyrimethamine is a potent inhibitor of multi-drug and toxin extrusion transporters. This compound inhibits Mdr-1(P-glycoprotein) and thus allows for active drugs to stay within the cell for longer periods of time, increasing their effectiveness by preventing efflux of the active compound from the cytoplasm. Pyrimethamine also inhibits DHFR(dihydrofolate reductase).
Pyrimethamine (CAS 58-14-0) References
- Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications. | Barnes, KI., et al. 2006. Clin Pharmacol Ther. 80: 582-96. PMID: 17178260
- Sulfadoxine-pyrimethamine for the treatment of malaria. | White, NJ. 1991. Trans R Soc Trop Med Hyg. 85: 556-7. PMID: 1755076
- Adverse Event Profile of Pyrimethamine-Based Therapy in Toxoplasmosis: A Systematic Review. | Ben-Harari, RR., et al. 2017. Drugs R D. 17: 523-544. PMID: 28879584
- Stability of a pyrimethamine suspension compounded from bulk powder. | Lewis, PO., et al. 2017. Am J Health Syst Pharm. 74: 2060-2064. PMID: 29222363
- A new effective antiplasmodial compound: Nanoformulated pyrimethamine. | Pestehchian, N., et al. 2020. J Glob Antimicrob Resist. 20: 309-315. PMID: 31404680
- Pyrimethamine conjugated histone deacetylase inhibitors: Design, synthesis and evidence for triple negative breast cancer selective cytotoxicity. | Wu, B., et al. 2020. Bioorg Med Chem. 28: 115345. PMID: 32061484
- Understanding the Pyrimethamine Drug Resistance Mechanism via Combined Molecular Dynamics and Dynamic Residue Network Analysis. | Amusengeri, A., et al. 2020. Molecules. 25: PMID: 32085470
- Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2. | Kim, DG., et al. 2020. Molecules. 25: PMID: 32549310
- Transgenic pyrimethamine-resistant plasmodium falciparum reveals transmission-blocking potency of P218, a novel antifolate candidate drug. | Posayapisit, N., et al. 2021. Int J Parasitol. 51: 635-642. PMID: 33713651
- The multifaceted antineoplastic role of pyrimethamine against human malignancies. | Ramchandani, S., et al. 2022. IUBMB Life. 74: 198-212. PMID: 34921584
- Pyrimethamine inhibits cell growth by inducing cell senescence and boosting CD8+ T-cell mediated cytotoxicity in colorectal cancer. | Dong, H., et al. 2022. Mol Biol Rep. 49: 4281-4292. PMID: 35262820
- Sulfadiazine Plus Pyrimethamine Therapy Reversed Multiple Behavioral and Neurocognitive Changes in Long-Term Chronic Toxoplasmosis by Reducing Brain Cyst Load and Inflammation-Related Alterations. | Castaño, BL., et al. 2022. Front Immunol. 13: 822567. PMID: 35572567
- Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity. | Rahman, Z., et al. 2023. Expert Opin Drug Deliv. 20: 301-311. PMID: 36639201
Inhibitor of:
γ-FR, ALDH1L2, AOX1, B7-H4, BC052484, C1orf25, C20orf54, C5orf25, COL17A1, cSHMT, DHFR, Folate, Folic Acid, FRP-1, HEXB, HRP-2, IFN-α9, LIFR, MATE1, Mdr-1, MFT, MITF, mSHMT, MSR, MTHFD2L, MTHFR, MTHFS, MTHFSD, P. falciparum infected RBCs, PCBD2, Plasmodium falciparum, Pneumocystis carinii, Skp1 p19, Stat5b, Su, THTPA, Toxoplasma gondii, and UBA2.Activator of:
ALKBH2, DHFR, DHFRL1, DTYMK, EG669998, GGH, GLB1L2, HCP1, HEXA, HISPPD2A, IFRG15, MAN2B1, MATE2, MTHFS, and RFC-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyrimethamine, 1 g | sc-208190 | 1 g | $80.00 | |||
Pyrimethamine, 5 g | sc-208190A | 5 g | $238.00 | |||
Pyrimethamine, 25 g | sc-208190B | 25 g | $825.00 |