Pyrimethamine (CAS 58-14-0)
Alternate Names:
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; Daraprim
Application:
Pyrimethamine is an inhibitor of P-glycoprotein and DHFR
CAS Number:
58-14-0
Purity:
≥95%
Molecular Weight:
248.71
Molecular Formula:
C12H13ClN4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Pyrimethamine is a potent inhibitor of multi-drug and toxin extrusion transporters. This compound inhibits Mdr-1(P-glycoprotein) and thus allows for active drugs to stay within the cell for longer periods of time, increasing their effectiveness by preventing efflux of the active compound from the cytoplasm. Pyrimethamine also inhibits DHFR(dihydrofolate reductase ).
References
Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983), Leport, C., et al.: Am. J. Med., 84, 94 (1988), McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998), Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004),
Physical State
:
Solid
Solubility
:
Soluble in Ethanol (hot)
Storage
:
Store at -20° C
Melting Point
:
233-2340°C (lit.)
Boiling Point
:
368.4° C at 760 mmHg
Density
:
~1.4 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID
:
4993
SMILES
:
CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
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