Molecular structure of Pemetrexed Disodium, CAS Number: 150399-23-8
Pemetrexed Disodium (CAS 150399-23-8)
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Alternate Names:
Pemetrexed Disodium is known as a Thymidylate synthase inhibitor.
Application:
Pemetrexed Disodium is a novel multitargeted antifolate antineoplastic agent and inhibitor of TS, DHFR and GARFT.
CAS Number:
150399-23-8
Purity:
≥98%
Molecular Weight:
471.37
Molecular Formula:
C20H19N5O6•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Pemetrexed disodium is a compound extensively studied for its role as an antifolate, primarily used in chemical and biochemical research. Its mechanism of action involves the inhibition of several folate-dependent enzymes, which are vital for the synthesis of nucleotides, thus impeding DNA and RNA synthesis. This mode of action makes it an interesting subject in the study of cell proliferation and the cell cycle, particularly in rapidly dividing cells. In research applications, it′s used to investigate the cellular response to folate pathway inhibition, including the examination of metabolic pathways and genetic factors that influence cell sensitivity or resistance to antifolates. Furthermore, pemetrexed disodium is utilized in the synthesis of novel compounds with potential biochemical or industrial applications.
Pemetrexed Disodium (CAS 150399-23-8) References
- Pemetrexed: a multitargeted antifolate agent with promising activity in solid tumors. | Adjei, AA. 2000. Ann Oncol. 11: 1335-41. PMID: 11106124
- Pemetrexed disodium, a novel antifolate with multiple targets. | Curtin, NJ. and Hughes, AN. 2001. Lancet Oncol. 2: 298-306. PMID: 11905785
- Interaction of pemetrexed disodium (ALIMTA, multitargeted antifolate) and irradiation in vitro. | Bischof, M., et al. 2002. Int J Radiat Oncol Biol Phys. 52: 1381-8. PMID: 11955753
- Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells. | Raymond, E., et al. 2002. Int J Oncol. 21: 361-7. PMID: 12118332
- Physical compatibility of pemetrexed disodium with other drugs during simulated Y-site administration. | Trissel, LA., et al. 2004. Am J Health Syst Pharm. 61: 2289-93. PMID: 15552637
- Genetic determinants of pemetrexed responsiveness and nonresponsiveness in non-small cell lung cancer cells. | Wu, MF., et al. 2010. J Thorac Oncol. 5: 1143-51. PMID: 20559153
- Development of a purity control strategy for pemetrexed disodium and validation of associated analytical methodology. | Warner, A., et al. 2015. J Pharm Biomed Anal. 105: 46-54. PMID: 25527981
- Synthesis and physicochemical characterization of the impurities of pemetrexed disodium, an anticancer drug. | Michalak, O., et al. 2015. Molecules. 20: 10004-31. PMID: 26035100
- Evaluation of the Effects of Astragalus membranaceus on the Pharmacokinetics of Pemetrexed Disodium and Gemcitabine in Rats by a Simple High-Performance Liquid Chromatography/UV Method. | Chu, Z., et al. 2019. J Anal Methods Chem. 2019: 3162426. PMID: 31183244
- Preparation and Evaluation of Stearylamine-Bearing Pemetrexed Disodium-Loaded Cationic Liposomes In Vitro and In Vivo. | He, K., et al. 2020. AAPS PharmSciTech. 21: 193. PMID: 32661922
- Pemetrexed Disodium Heptahydrate Induces Apoptosis and Cell-cycle Arrest in Non-small-cell Lung Cancer Carrying an EGFR Exon 19 Deletion. | Mohiuddin, M. and Kasahara, K. 2021. Anticancer Res. 41: 2963-2977. PMID: 34083287
- Cisplatin and Pemetrexed Have Distinctive Growth-inhibitory Effects in Monotherapy and Combination Therapy on KRAS-dependent A549 Lung Cancer Cells. | Mohiuddin, M. and Kasahara, K. 2021. Cancer Genomics Proteomics. 18: 579-590. PMID: 34183390
- Study on co-delivery of pemetrexed disodium and Bcl-2 siRNA by poly-γ-glutamic acid-modified cationic liposomes for the inhibition of NSCLC. | Huang, X., et al. 2023. Drug Dev Ind Pharm. 49: 62-74. PMID: 36803267
Inhibitor of:
AICAR transformylase, C20orf54, DHFR, FRP-1, Gm20172, MFT, mSHMT, PPC Synthetase, Su, THTPA, TMSL3, TS, and xCT.Activator of:
α-FR, DTYMK, FPGS, and GGH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pemetrexed Disodium, 10 mg | sc-219564 | 10 mg | $133.00 |