FOXJ2 Activators
FOXJ2 activators are a category of chemical compounds that serve to regulate the activity of the FOXJ2 protein, a member of the forkhead box (FOX) family of transcription factors characterized by a distinct DNA-binding forkhead box domain. FOXJ2 is involved in the transcriptional regulation of genes associated with cellular processes such as the cell cycle, apoptosis, and differentiation.
The activation of FOXJ2 by these chemicals can be achieved through either direct or indirect means. Direct activators would likely interact with FOXJ2 at a molecular level, potentially by binding to the protein and inducing conformational changes that enhance its DNA-binding affinity and transcriptional activity, or by stabilizing the protein to prevent its degradation. Such binding could also facilitate the recruitment of coactivators necessary for transcription initiation or enhance the protein's nuclear localization, ensuring that it is in the correct subcellular compartment to perform its function. Indirect activators may operate through various pathways that converge on the regulation of FOXJ2. These could include modulating signaling pathways that affect FOXJ2's phosphorylation state, influencing its activity, or altering the expression levels of FOXJ2 itself through upstream transcriptional regulators. In addition, indirect activators might affect the proteostasis of FOXJ2, modulating the protein's stability and turnover.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin is a potent activator of the PI3K/AKT pathway, which is known to control FOXJ2. By stimulating this pathway, insulin can result in an increase in FOXJ2 transcription. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which then stimulates the AKT pathway and subsequently enhances FOXJ2 transcription. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, leading to a compensatory activation of the PI3K/AKT pathway, which could indirectly enhance FOXJ2 transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, activating protein kinase A (PKA). PKA can stimulate the PI3K/AKT pathway, potentially increasing FOXJ2 transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which has been shown to interact with the PI3K/AKT pathway. This interaction can potentially lead to an increase in FOXJ2 transcription. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin activates AMPK, which in turn can inhibit mTOR. This inhibition could lead to a compensatory activation of the PI3K/AKT pathway, potentially enhancing FOXJ2 transcription. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, which can indirectly modulate the PI3K/AKT pathway, and subsequently FOXJ2 transcription. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 inhibits the V-ATPase, leading to a compensatory activation of the PI3K/AKT pathway. This activation could indirectly enhance FOXJ2 transcription. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is an mTOR inhibitor that can lead to a compensatory activation of the PI3K/AKT pathway under certain conditions, potentially enhancing FOXJ2 transcription. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $207.00 | 8 | |
Dactolisib inhibits PI3K and mTOR, leading to a compensatory activation of the PI3K/AKT pathway, potentially enhancing FOXJ2 transcription. | ||||||