Formin 1 Activators
Formin 1 activators belong to a specialized chemical class that plays a pivotal role in cellular processes, particularly in the regulation of the actin cytoskeleton. Formin 1, a member of the formin family of proteins, acts as a nucleator for actin filament assembly, facilitating the polymerization of globular actin (G-actin) into filamentous actin (F-actin). This process is crucial for various cellular functions, including cell motility, division, and shape maintenance. Formin 1 activators are compounds or molecules that enhance the activity of Formin 1, thereby promoting actin polymerization and influencing the dynamics of the cytoskeleton.
The activation of Formin 1 by these specialized compounds involves a finely tuned molecular interplay. Formin 1 activators typically interact with specific regions of the Formin 1 protein, modulating its conformation and promoting its nucleation activity. This activation leads to the elongation of actin filaments, which, in turn, influences cellular processes such as cell migration and adhesion. The intricate control of actin dynamics mediated by Formin 1 activators highlights their significance in the underlying mechanisms of cellular architecture and function. Understanding the molecular details of Formin 1 activation provides valuable insights into the intricate regulatory networks governing cellular morphology and motility, offering potential avenues for further research and exploration in the realms of cell biology and biochemistry.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibits mDia formins, a subtype of diaphanous-related formin (DRF), suggesting a potential indirect modulation of Formin-1 activation. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Disrupts actin polymerization, a process integral to Formin-1 function and the activation of the actin cytoskeleton. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $92.00 $449.00 | 6 | |
Inhibits group I PAKs, part of the signaling pathways influencing cytoskeleton regulation, potentially activating Formin-1 indirectly. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits Rho-associated protein kinase (ROCK), a downstream effector of Rho GTPases, influencing actin dynamics and potentially activating Formin-1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits phosphoinositide 3-kinase (PI3K), a kinase involved in signaling pathways that intersect with cytoskeletal regulation, potentially activating Formin-1 indirectly. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Inhibits tankyrase, a component of the Wnt signaling pathway, suggesting a potential indirect impact on Formin-1 through Wnt pathway activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), implicated in signaling pathways affecting the cytoskeleton and potentially activating Formin-1. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Inhibits protein kinase C (PKC), impacting signaling pathways related to cytoskeletal regulation and potentially activating Formin-1 indirectly. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Serves as an intracellular calcium chelator, influencing calcium-dependent processes crucial for Formin-1-mediated cytoskeletal dynamics and activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits the mechanistic target of rapamycin (mTOR), a kinase involved in cell growth signaling, potentially affecting processes related to Formin-1 activation. | ||||||