Formin 1 Antibody (H-5): sc-515698

Formin 1 Antibody (H-5) is a mouse monoclonal IgM antibody that detects Formin 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Formin 1 (H-5) antibody is available as the non-conjugated anti-Formin 1 monoclonal isotype antibody. Formin 1 plays a vital role in cytoskeletal dynamics, particularly in the assembly of actin filaments, which are essential for various cellular processes, including cell shape, motility, and division. Formin 1 is predominantly located in the cytoplasm but can also translocate to the nucleus, where Formin 1 influences gene expression and cellular signaling pathways. Formin 1′s ability to interact with the actin cytoskeleton is crucial for maintaining cellular integrity and facilitating proper development of tissues, particularly during limb formation. Disruptions in Formin 1 function can lead to significant developmental defects, as seen in mutations at the limb deformity locus in mammals, which can result in severe limb and kidney malformations. Understanding Formin 1′s role in these processes is essential for elucidating mechanisms underlying developmental syndromes and exploring potential therapeutic targets in related conditions. The human Formin 1 gene is located on chromosome 15q13.3, highlighting Formin 1′s evolutionary conservation and importance across species.

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Formin 1 Antibody (H-5) References:

1. Formin defines a large family of morphoregulatory genes and functions in establishment of the polarising region.  |  Zeller, R., et al. 1999. Cell Tissue Res. 296: 85-93. PMID: 10199968
2. Formin family proteins in cytoskeletal control.  |  Tanaka, K. 2000. Biochem Biophys Res Commun. 267: 479-81. PMID: 10631086
3. Formin-2, a novel formin homology protein of the cappuccino subfamily, is highly expressed in the developing and adult central nervous system.  |  Leader, B. and Leder, P. 2000. Mech Dev. 93: 221-31. PMID: 10781961
4. Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells.  |  O'Rourke, DA., et al. 2000. J Am Soc Nephrol. 11: 2212-2221. PMID: 11095644
5. Cell polarity: following formin function.  |  Sawin, KE. 2002. Curr Biol. 12: R6-8. PMID: 11790314
6. A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs.  |  Maas, RL., et al. 1991. Am J Hum Genet. 48: 687-95. PMID: 1673046
7. The role of a single formin isoform in the limb and renal phenotypes of limb deformity.  |  Wynshaw-Boris, A., et al. 1997. Mol Med. 3: 372-84. PMID: 9234242

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Formin 1 Antibody (H-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Formin 1 Antibody (H-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Formin 1 Antibody (H-5) Specifications

Alternate Product Name: Formin 1

Product Clone Name: H-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 371-392

Epitope Target: Formin 1

Epitope Species: human

Product Reactivity/Detection: Formin 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Formin 1 Antibody (H-5): N/A