FMR2 Inhibitors
Chemical inhibitors of FMR2 can function through various non-transcriptional mechanisms to impede its activity. Phlorizin disrupts the sodium-glucose transport proteins, leading to a reduction in intracellular glucose levels, which in turn can decrease the levels of ATP necessary for FMR2's activity. Similarly, Bisphenol A, with its endocrine-disrupting capabilities, can alter cellular signaling pathways where FMR2 is active, thereby indirectly inhibiting its function. Genistein, as a tyrosine kinase inhibitor, may interrupt phosphorylation processes that are crucial for the functional state of FMR2, leading to its inhibition. Curcumin, on the other hand, exerts its effects by modulating multiple signaling pathways and can disrupt protein-protein interactions that are essential for the activity of FMR2.
Resveratrol acts on sirtuin pathways, which can lead to alterations in signaling cascades involving FMR2, culminating in its functional inhibition. LY294002 and Wortmannin, both PI3K inhibitors, and Triciribine, an Akt inhibitor, target the PI3K/Akt signaling pathway. By disrupting this pathway, they can indirectly inhibit FMR2's roles that are regulated by or dependent on these signaling events. Rapamycin, an mTOR inhibitor, by altering the regulatory pathways of cell growth and metabolism, can influence the cellular environment and signaling where FMR2 operates. SB203580 and PD98059, inhibitors of p38 MAPK and MEK respectively, can impede signaling pathways that may involve FMR2, thereby inhibiting its function. U0126, another MEK inhibitor, similarly disrupts ERK pathway signaling, which could lead to indirect functional inhibition of FMR2 through these altered pathways.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloridzin dihydrate | 7061-54-3 | sc-215708 sc-215708A | 250 mg 1 g | $48.00 $117.00 | ||
Phlorizin inhibits sodium-glucose transport proteins, potentially reducing ATP levels and indirectly leading to functional inhibition of FMR2, which may require ATP for its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, as a tyrosine kinase inhibitor, may disrupt phosphorylation-dependent signaling pathways that FMR2 is part of, thereby indirectly inhibiting the functional activity of FMR2. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A can interfere with endocrine signaling pathways. Disruption of these pathways can alter cellular function in a way that indirectly inhibits the activity of FMR2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to modulate multiple signaling pathways. Its action can lead to altered protein-protein interactions, potentially inhibiting the function of FMR2 within these pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences sirtuin activity and may disrupt downstream signaling that involves FMR2, leading to an indirect functional inhibition of FMR2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can disrupt PI3K/Akt signaling, a pathway where FMR2 might have a role, thus indirectly inhibiting FMR2's function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and metabolism, which could indirectly affect FMR2's function by altering cellular contexts and signaling where FMR2 operates. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor; by inhibiting p38 MAPK signaling, it may indirectly affect signaling cascades that involve FMR2, thus potentially inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is upstream of ERK signaling. As ERK signaling can regulate numerous proteins, inhibiting this pathway may indirectly lead to functional inhibition of FMR2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor like LY294002, and by inhibiting PI3K/Akt signaling, it may indirectly affect the pathways that involve FMR2's function within the cell. | ||||||