FLJ10081 Activators
Forskolin and Ionomycin target cyclic AMP and calcium levels respectively, which are universal secondary messengers that can impact the activity of a wide range of proteins within the cell. Compounds such as PMA and LY294002 specifically activate or inhibit key signaling enzymes like PKC and PI3K, with downstream effects that could extend to proteins like FLJ10081. Similarly, PD98059, SB203580, SP600125, and U0126 provide a range of kinase inhibitors which have the ability to modulate key regulatory pathways such as the ERK/MAPK, p38 MAPK, and JNK pathways. Alterations in these pathways may influence the phosphorylation state and function of FLJ10081.
Rapamycin is included for its ability to inhibit mTOR, a central regulator of cell growth and protein synthesis, which could impact the overall protein homeostasis and thereby the levels of FLJ10081. Calcium signaling modulators such as W-7 and KN-93, which inhibit calmodulin and CaMKII, respectively, offer potential routes to affect proteins regulated by calcium-dependent processes. Finally, 2-APB acts on intracellular calcium release channels, which can have a broad impact on cellular calcium signaling and potentially affect the activity of FLJ10081.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase, leading to increased cAMP levels, which may enhance protein kinase A (PKA) activity and could modulate the phosphorylation state of FLJ10081. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium levels, potentially activating calcium-dependent protein kinases that may alter the activity or conformation of FLJ10081. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which may phosphorylate FLJ10081 or proteins that interact with FLJ10081, possibly affecting its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits the PI3K/Akt pathway, possibly leading to alterations in downstream signaling that could affect the localization, stability, or activity of FLJ10081. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, which may alter the ERK/MAPK signaling pathway, potentially affecting the phosphorylation and activity of FLJ10081. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAPK, potentially influencing pathways that regulate stress responses, which could affect the function of FLJ10081. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
Inhibits JNK, possibly affecting the stress-activated signaling pathways and modulating the activity of FLJ10081. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of MEK1/2, potentially affecting the ERK/MAPK pathway and possibly influencing the phosphorylation state of FLJ10081. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits the mTOR pathway, which may impact the synthesis and degradation of proteins, potentially affecting the levels and activity of FLJ10081. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
Inhibits calmodulin, which can affect calcium signal transduction pathways, potentially influencing the activity of FLJ10081. | ||||||