Flg Activators
FIg (FGFR1) Activators are a diverse class of chemicals that focus on upregulating the activity or expression of Fibroblast Growth Factor Receptor 1 (FGFR1). FGFR1 is a cell-surface receptor for fibroblast growth factors and is involved in various biological processes, including cell growth, differentiation, and migration. The most direct way to influence FGFR1 is through its kinase domain. Chemicals like SU5402, PD166866, and AZD4547 are known to interact directly with this domain, thereby enhancing the receptor's signaling capacity. These compounds specifically aim at activating the kinase activity, allowing FGFR1 to phosphorylate downstream substrates and execute its cellular functions.
Indirect activators employ various biochemical routes to influence FGFR1. For instance, Pentagastrin and Glucagon can increase FGFR1 expression by manipulating secondary messengers like cAMP. Then there are compounds like Daidzein and Genistein that modulate FGFR1 expression via interaction with estrogen receptors. The polyphenols Curcumin and Luteolin act on multiple pathways to upregulate FGFR1 expression. Similarly, Capsaicin activates TRPV1, leading to an influx of calcium ions that can, in turn, influence FGFR1. Lastly, Eicosapentaenoic Acid (EPA) can modulate cellular processes that eventually enhance FGFR1 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $63.00 $98.00 | 36 | |
Directly targets FGFR1 kinase domain, increasing activation. | ||||||
AZD4547 | 1035270-39-3 | sc-364421 sc-364421A | 5 mg 10 mg | $198.00 $309.00 | 6 | |
Acts on the kinase domain, enhancing FGFR1 activity. | ||||||
Pentagastrin | 5534-95-2 | sc-499379 | 1 mg | $235.00 | ||
Increases FGFR1 expression via gastrin release. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Increases FGFR1 expression through activation of various pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, which can elevate FGFR1 expression. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
Enhances FGFR1 activity through modulating cellular processes. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $28.00 $79.00 $165.00 | 32 | |
Increases FGFR1 expression through estrogen receptor modulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Similar to Daidzein, affects FGFR1 via estrogen receptors. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Activates TRPV1, increasing intracellular calcium and thereby FGFR1 expression. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Acts on multiple signaling pathways to upregulate FGFR1 expression. | ||||||