FLASH Activators
The chemical class known as FLASH Activators comprises compounds that can modulate the activity or expression of the FLASH protein, also known as CASP8AP2. FLASH plays a critical role in multiple cellular processes, particularly in mRNA splicing, which is essential for generating mature RNA transcripts from pre-mRNA molecules. Several mechanisms can activate FLASH through these compounds. For example, topoisomerase inhibitors like Camptothecin and Etoposide induce DNA damage and p53-dependent apoptosis. FLASH becomes involved in mRNA splicing and apoptotic regulation as part of the cellular response to DNA damage, potentially leading to changes in splicing patterns during apoptosis. Another class of activators, such as Actinomycin D, disrupts transcription by inhibiting RNA polymerase. This inhibition can indirectly impact FLASH because it is involved in mRNA splicing, and changes in transcription can influence the substrates available for splicing. Agents like Doxorubicin and Cisplatin, which induce DNA damage and apoptosis, may trigger changes in mRNA splicing patterns, where FLASH plays a crucial role.
Staurosporine, a kinase inhibitor, can activate apoptosis, and FLASH might participate in splicing regulation during this process. Nutlin-3, a p53-MDM2 interaction inhibitor, may influence FLASH through p53 signaling pathways, as p53 can modulate apoptosis and splicing. Epigenetic changes induced by Azacitidine, a DNA methyltransferase inhibitor, might indirectly affect FLASH as it participates in mRNA splicing events, which can be influenced by alterations in DNA methylation patterns. Additionally, compounds like 5-Fluorouracil, Tunicamycin, and Sorafenib can indirectly impact FLASH by perturbing cellular processes interconnected with FLASH's mRNA splicing functions, including nucleotide metabolism, ER stress response, and cellular signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that induces DNA damage and activates p53-mediated apoptotic pathways. FLASH may become involved in mRNA splicing and apoptotic regulation as part of the cellular response to DNA damage. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is another topoisomerase II inhibitor that causes DNA damage and activates p53-dependent apoptosis. FLASH may participate in mRNA splicing changes during apoptosis triggered by etoposide treatment. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D is an inhibitor of RNA polymerase that can disrupt transcription processes. FLASH, involved in mRNA splicing, may be indirectly influenced as a result of altered transcription. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin is a chemotherapy drug that generates DNA damage and promotes apoptosis. FLASH could play a role in mRNA splicing events occurring during doxorubicin-induced cell death. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin is known for its DNA cross-linking ability, causing DNA damage and initiating apoptosis. FLASH may contribute to splicing changes associated with apoptosis induction. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that induces apoptosis. FLASH might be involved in splicing regulation during the apoptotic response triggered by staurosporine. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 inhibits the p53-MDM2 interaction, potentially influencing FLASH through p53 signaling pathways. As p53 can modulate apoptosis and splicing, Nutlin-3 might indirectly affect FLASH. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can alter DNA methylation patterns. FLASH may be indirectly impacted as it participates in mRNA splicing events, which can be influenced by epigenetic changes. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil interferes with nucleotide metabolism and DNA synthesis. FLASH may indirectly respond to alterations in cellular processes triggered by this chemotherapy drug. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin induces endoplasmic reticulum (ER) stress by inhibiting N-linked glycosylation. FLASH may be affected as part of the ER stress response, potentially altering its splicing functions. | ||||||