FKBP9 Activators
FKBP9 Activators are a selection of chemical compounds that indirectly augment the functional activity of FKBP9 through modulation of various cellular pathways and stress responses. Cyclosporin A and FK506 (Tacrolimus) bind directly to FKBP9, inhibiting its prolyl isomerase activity, which paradoxically leads to an enhancement of FKBP9's function due to a decreased competition with other cellular pathways. Rapamycin also forms a complex with FKBP9 and through the inhibition of the mTOR pathway, induces autophagy, a process that FKBP9 is thought to be involved in, subsequently enhancing its activity. Additionally, Pimecrolimus acts in a similar fashion to Tacrolimus, modulating calcineurin activity and potentially enhancing FKBP9's functions. Chemical chaperones like Sodium phenylbutyrate and Trimethylamine N-oxide (TMAO) contribute to the proper folding of FKBP9, thereby promoting its functional stability and activity. Zinc pyrithione,through its oxidative stress induction, could activate heat shock responses that heighten the functional demand for chaperones like FKBP9, indirectly increasing its activity.
The functional activity of FKBP9 is further influenced by compounds that modulate the cellular stress response. Geldanamycin and 17-AAG (Tanespimycin), both Hsp90 inhibitors, trigger a heat shock response which may lead to a compensatory increase in FKBP9 activity to meet elevated chaperone demands. Dimethyl sulfoxide (DMSO) and Trehalose, recognized for their protein-stabilizing effects, may indirectly enhance FKBP9 activity by improving its structural stability and preventing protein aggregation. Geranylgeranylacetone, known to induce heat shock proteins, could similarly boost the functional role of FKBP9 by increasing the cellular requirement for molecular chaperones. Collectively, these FKBP9 Activators, through their targeted effects on protein folding and cellular stress pathways, facilitate the enhancement of FKBP9-mediated functions without the need for upregulating its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A binds to the immunophilin FKBP9, inhibiting its prolyl isomerase activity, which leads to the suppression of calcineurin activity. This reduction in calcineurin activity indirectly enhances the functional activity of FKBP9. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin forms a complex with FKBP9, inhibiting the mTOR pathway. This inhibition can lead to a compensatory increase in autophagy, a process in which FKBP9 is thought to be involved, thereby enhancing its functional activity. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK506, like Cyclosporin A, binds to FKBP9 and inhibits its peptidyl-prolyl isomerase activity. This inhibition indirectly enhances FKBP9's activity by reducing competitive interactions with other cellular targets. | ||||||
Pimecrolimus | 137071-32-0 | sc-208172 | 1 mg | $140.00 | 2 | |
Pimecrolimus, an ascomycin macrolactam derivative, binds to FKBP9 and similarly to Tacrolimus, inhibits calcineurin, which may indirectly enhance the specific activity of FKBP9 by reducing competition from other prolyl isomerases. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
Sodium phenylbutyrate acts as a chemical chaperone, potentially enhancing the proper folding and function of proteins including FKBP9, especially under stress conditions that may involve protein misfolding. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc pyrithione can act as a mild oxidative stress inducer. This stress can lead to the activation of heat shock response and increased demand for molecular chaperones, including FKBP9, thereby potentially enhancing its activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin binds to Hsp90, inhibiting its function. This leads to the activation of heat shock response, which could increase the functional demand for other chaperones, including FKBP9, thus indirectly enhancing its activity. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG is an Hsp90 inhibitor like Geldanamycin and has a similar effect by inducing a heat shock response that may upregulate the functional role of FKBP9 as a compensatory mechanism. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO can stabilize proteins and enhance their folding, which may indirectly increase the functional activity of FKBP9 by improving its overall stability and proper folding. | ||||||
Geranylgeranylacetone | 6809-52-5 | sc-252851 sc-252851A | 10 mg 100 mg | $65.00 $155.00 | 2 | |
Geranylgeranylacetone has been shown to induce the expression of heat shock proteins, which could lead to an increased functional demand and activity of molecular chaperones, including FKBP9. | ||||||