FIV p27 Activators
FIV p27 is a core protein of the Feline Immunodeficiency Virus, which plays a pivotal role in the viral replication cycle. As a major structural protein, p27 is crucial for the assembly and maturation of the virus, ensuring the integrity and infectivity of the viral particles. In the life cycle of FIV, the regulation of p27 expression is tightly controlled by the viral genetic program. The protein is not expressed constitutively in infected cells but is produced in significant quantities during active viral replication. Understanding the regulation of p27 expression is important for comprehending the pathogenesis of the virus and the progression of the disease in infected felines.
The expression of viral proteins like FIV p27 can be influenced by various chemical activators that interact with cellular pathways. These activators can potentially induce the expression of p27 by engaging with different molecular mechanisms. For instance, compounds that inhibit histone deacetylases (HDACs) can cause changes to the chromatin structure around viral DNA, potentially leading to increased transcription of viral genes and the subsequent synthesis of viral proteins. Similarly, activators of protein kinase C (PKC) have been known to trigger signaling cascades that could result in the reactivation of latent viruses, prompting a surge in viral protein production. Other chemical activators may include DNA methyltransferase inhibitors, which by altering the methylation status of viral DNA, could lead to the upregulation of viral gene expression and protein production. Each activator works through a unique pathway, and their potential to increase the expression of FIV p27 highlights the complex interplay between viral and cellular regulatory mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $138.00 $530.00 | 24 | |
Prostratin, through its activation of protein kinase C, could theoretically lead to the reactivation of latent FIV, subsequently increasing the synthesis of the p27 protein by promoting viral transcription. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
By targeting protein kinase C, Bryostatin 1 may stimulate the viral life cycle of FIV. This could lead to a rise in p27 production as a result of enhanced viral gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, as a histone deacetylase inhibitor, has the potential to open chromatin structure, thereby upregulating the transcription of FIV genes, including those encoding the p27 protein. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid is known to increase acetylation of histones, potentially leading to a more accessible chromatin state in the region of the FIV genome, which may result in the upsurge of p27 capsid protein synthesis. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, by inhibiting histone deacetylase, may stimulate the FIV to exit latency. This could lead to an increase in viral replication and the subsequent synthesis of the p27 protein. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid has been reported to induce apoptosis in HIV-infected cells. Similar action in FIV could lead to the activation of viral replication pathways, potentially upregulating p27 protein production. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram has been noted to reactivate latent HIV through modification of proteasome function, and a similar mechanism may lead to the reactivation of FIV, resulting in enhanced p27 protein production. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA's activation of protein kinase C can lead to the transcriptional activation of FIV genes, potentially leading to an increase in the production of the p27 protein as part of the viral replication process. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 disrupts the interaction of BET bromodomain proteins with acetylated histones, which may lead to an upsurge in the transcription of viral genes, including those coding for the p27 protein in FIV. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat, by inhibiting histone deacetylases, may lead to the reactivation of the FIV from latency, potentially resulting in the increased synthesis of the p27 protein. | ||||||