FIP1L1 Activators
FIP1L1 activators are a class of chemical compounds that influence the activity of the FIP1L1 protein, which is a part of a fusion gene created by the genetic anomaly known as the FIP1L1-PDGFRA fusion. This fusion involves the FIP1-like 1 (FIP1L1) gene and the platelet-derived growth factor receptor alpha (PDGFRA) gene. The FIP1L1 gene itself is significant as it encodes a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex that is essential in the regulation of mRNA processing, particularly in the cleavage and polyadenylation of the 3' end of pre-mRNA. The FIP1L1 activators, by modulating this protein, may affect a wide range of cellular processes due to the fundamental role of CPSF in mRNA maturation and, consequently, gene expression.
The chemical nature of FIP1L1 activators can vary widely, with each activator having a distinct molecular structure and mechanism of action for influencing FIP1L1 activity. These compounds often interact with the protein at a molecular level, which can result in changes to its conformation, stability, or interaction with other proteins and molecules within the cell. As FIP1L1 is involved in the intricate process of mRNA maturation, the activators may have a profound impact on the post-transcriptional control of gene expression. Such regulation could potentially affect multiple signaling pathways and cellular functions. It's important to note that the study of FIP1L1 activators is grounded in the understanding of molecular biology and biochemistry, focusing on the fundamental aspects of cell function and protein interaction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels in cells, which can influence pathways that modulate mRNA processing and may indirectly increase the function or expression of FIP1L1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterase, preventing degradation of cAMP and potentially enhancing signaling pathways that could indirectly activate FIP1L1 by stabilizing mRNAs or altering their processing. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
As a selective inhibitor of phosphodiesterase 4, Rolipram increases cAMP levels, potentially impacting RNA processing factors including FIP1L1 through cAMP-responsive elements. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to affect glycogen synthase kinase-3 (GSK-3) activity, which might indirectly influence factors involved in mRNA processing, potentially including FIP1L1, by altering phosphorylation states. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor and can lead to changes in gene expression that might include upregulation of proteins involved in mRNA processing, potentially influencing FIP1L1 activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Similar to sodium butyrate, Trichostatin A inhibits histone deacetylases leading to altered gene expression patterns, which could indirectly affect mRNA processing proteins including FIP1L1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid affects gene expression through retinoic acid receptors, potentially altering the expression of proteins involved in mRNA processing and impacting the activity or stability of FIP1L1. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine can affect gene expression patterns, possibly leading to changes in the levels or activity of RNA processing proteins, including FIP1L1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG modulates various signaling pathways and could influence the cellular environment in a way that indirectly increases the function or expression of mRNA processing proteins such as FIP1L1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
It is a cell-permeable cAMP analog that mimics the effects of cAMP and could thereby modulate the activity of proteins involved in mRNA processing, potentially impacting FIP1L1. | ||||||