Fibrosin-like 1 Activators
Fibrosin-like 1 Activators are a curated set of chemical compounds that amplify the protein's activity via distinct cellular mechanisms. Forskolin, known for its ability to elevate cAMP levels, indirectly bolsters the function of Fibrosin-like 1 by activating PKA, which may phosphorylate proteins that modulate Fibrosin-like 1's structure or localization. Similarly, IBMX prolongs the life of cAMP and cGMP in the cell, enhancing PKA and PKG pathways, which can influence the conformation and function of Fibrosin-like 1. Sphingosine-1-phosphate and PMA, through activation of the PI3K/AKT and PKC pathways respectively, potentially facilitate post-translational modifications of Fibrosin-like 1, thereby augmenting its activity. Dibutyryl-cAMP, as a cAMP analog, continues this theme of PKA activation, suggesting a common regulatory theme in Fibrosin-like 1 activation through cAMP-responsive elements.
Conversely, certain kinase inhibitors like Epigallocatechin gallate, LY294002, U0126, PD 98059, and Staurosporine offer an alternative route for enhancing Fibrosin-like 1 activity. By inhibiting kinases that may negatively regulate Fibrosin-like 1, they could indirectly contribute to its increased activity. The dynamic interplay of kinase inhibition and activation is a crucial aspect of cellular signaling that affects Fibrosin-like 1. Moreover, compounds that modulate intracellular calcium levels, such as A23187 and Thapsigargin, elicit effects on calcium-dependent signaling pathways, potentially leading to the activation of Fibrosin-like 1. These activators work through complex intracellular pathways, converging on the common endpoint of increased functional activity of Fibrosin-like 1, without upregulating its expression or requiring direct activation by ligand binding.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA (Protein Kinase A), which can phosphorylate various targets that may interact with or enhance the activity of Fibrosin-like 1 by altering its conformation or localization. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP. This results in an accumulation of these molecules, potentiating PKA and PKG pathways, potentially enhancing Fibrosin-like 1 activity by similar mechanisms as Forskolin. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) acts on its receptors to activate intracellular signaling cascades, including the PI3K/AKT pathway, which can lead to cellular changes that might enhance the activity or stability of Fibrosin-like 1 through post-translational modifications. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC), which phosphorylates a wide range of targets. Activation of PKC could lead to the phosphorylation of proteins that interact with Fibrosin-like 1, enhancing its activity or stability within the cell. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol that inhibits several protein kinases. This inhibition could reduce negative regulatory phosphorylation events, potentially leading to an increased activity of Fibrosin-like 1 through relief of inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that may lead to a compensatory response in cells, increasing the activity of compensatory pathways that could enhance the activity or expression of Fibrosin-like 1 through feedback mechanisms. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, activating calcium-dependent kinases and phosphatases, which could lead to the activation of Fibrosin-like 1 through calcium signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog, which activates PKA and could mimic cAMP's effect in enhancing the activity of Fibrosin-like 1 by phosphorylation or changes in protein-protein interactions that positively affect Fibrosin-like 1 function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor, which may paradoxically enhance the activity of Fibrosin-like 1 by inhibiting kinases that negatively regulate it, resulting in a net positive effect on Fibrosin-like 1 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which works similarly to U0126 and could affect Fibrosin-like 1 activity by altering the balance of cellular signaling pathways, potentially enhancing pathways that indirectly activate Fibrosin-like 1. | ||||||