FBXW18 Inhibitors
FBXW18, a member of the F-box protein family, plays a crucial role in cellular homeostasis by participating in the regulation of protein turnover. Functionally, FBXW18 operates as a component of the SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complex, contributing to the ubiquitination and subsequent degradation of specific target proteins. The primary function of FBXW18 lies in its ability to recognize substrate proteins and facilitate their ubiquitination, marking them for degradation by the proteasome.
The inhibition of FBXW18 is intricately linked to cellular processes influenced by various signaling pathways and molecular events. FBXW18 targets proteins involved in critical pathways such as the PI3K/Akt, NF-κB, TGF-β/SMAD, and cell cycle regulation. The chemicals listed in the table act as inhibitors either directly or indirectly, disrupting these pathways and leading to the inhibition of FBXW18. For example, AZD-8055 inhibits mTOR, impacting FBXW18 indirectly through the mTOR pathway, while JQ1 modulates transcriptional events, influencing FBXW18 indirectly by altering gene expression patterns. In summary, FBXW18 inhibitors serve as valuable tools for unraveling the intricate network of cellular processes governed by FBXW18. The modulation of FBXW18 activity through these inhibitors provides insights into the regulatory mechanisms orchestrating protein turnover and cellular homeostasis.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
mTOR inhibitor influencing FBXW18 indirectly through the mTOR pathway. By blocking mTOR, AZD-8055 disrupts downstream events, altering cellular processes associated with FBXW18 regulation. This leads to the inhibition of FBXW18 through the modulation of mTOR-dependent signaling cascades. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
G9a histone methyltransferase inhibitor indirectly affecting FBXW18 by modulating epigenetic regulation. BIX-01294 alters histone methylation patterns, influencing gene expression and thereby disrupting cellular processes connected to FBXW18. This leads to the inhibition of FBXW18 through epigenetic modulation of its regulatory network. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
CBP/p300 histone acetyltransferase inhibitor indirectly influencing FBXW18 through epigenetic modulation. C646 alters histone acetylation patterns, impacting gene expression and disrupting cellular processes associated with FBXW18. This leads to the inhibition of FBXW18 through epigenetic control of its regulatory mechanisms. | ||||||
GSK-J4 | 1373423-53-0 | sc-507551 | 100 mg | $1275.00 | ||
JMJD3 histone demethylase inhibitor indirectly affecting FBXW18 by modulating epigenetic regulation. GSK-J4 alters histone methylation patterns, influencing gene expression and disrupting cellular processes connected to FBXW18. This leads to the inhibition of FBXW18 through epigenetic modulation of its regulatory network. | ||||||
IKK 16 | 1186195-62-9 | sc-204009 sc-204009A | 10 mg 50 mg | $223.00 $942.00 | 2 | |
IKKβ inhibitor impacting NF-κB signaling pathway, indirectly influencing FBXW18. By inhibiting IKKβ, IKK-16 disrupts downstream events, altering cellular processes associated with FBXW18 regulation. This leads to the inhibition of FBXW18 through the modulation of NF-κB-dependent signaling cascades. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Bromodomain and extraterminal domain (BET) protein inhibitor indirectly affecting FBXW18 by modulating transcriptional events. By inhibiting BET proteins, JQ1 alters the expression of genes involved in pathways associated with FBXW18, disrupting its regulatory network and leading to inhibition. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
Akt inhibitor influencing FBXW18 indirectly through the PI3K/Akt pathway. By blocking Akt, MK-2206 disrupts downstream events, altering cellular processes associated with FBXW18 regulation. This leads to the inhibition of FBXW18 through the modulation of PI3K/Akt-dependent signaling cascades. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
MDM2 inhibitor impacting p53 signaling pathway, indirectly influencing FBXW18. By inhibiting MDM2, Nutlin-3 disrupts downstream events, altering cellular processes associated with FBXW18 regulation. This leads to the inhibition of FBXW18 through the modulation of p53-dependent signaling cascades. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
CDK4/6 inhibitor influencing FBXW18 indirectly through cell cycle regulation. By blocking CDK4/6, PD 0332991 disrupts cell cycle progression, altering cellular processes associated with FBXW18 regulation. This leads to the inhibition of FBXW18 through the modulation of CDK4/6-dependent cell cycle pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor indirectly inhibiting FBXW18 by disrupting p38 MAPK-mediated signaling pathways. By inhibiting p38 MAPK, SB 203580 alters downstream events, impacting cellular processes associated with FBXW18 regulation. This leads to the inhibition of FBXW18 through the modulation of p38 MAPK-dependent signaling cascades. | ||||||