Fbxo12J Inhibitors
The chemical class Fbxo12J Inhibitors includes a diverse range of compounds that influence the ubiquitin-proteasome system (UPS), a cellular pathway that Fbxo12J is associated with through its role in protein ubiquitination. These compounds can affect the activity of Fbxo12J by either inhibiting the proteasome itself, thereby preventing the degradation of proteins that Fbxo12J may target, or by inhibiting upstream enzymes in the ubiquitination cascade, such as E1 or NEDD8-activating enzymes. By doing so, they alter the turnover of proteins within the cell, which can have a significant impact on various cellular processes and signaling pathways.
MG132, Bortezomib, Lactacystin, and Epoxomicin are all proteasome inhibitors that prevent the breakdown of ubiquitinated proteins. This can lead to the accumulation of Fbxo12J substrates and may indirectly affect the protein's function. PYR-41 and MLN4924 (Pevonedistat) target upstream enzymatic activities necessary for the ubiquitination process, potentially reducing the functional impact of Fbxo12J on its substrate proteins. Compounds like Nutlin-3, Celastrol, Thalidomide, Withaferin A, and Oprozomib all modulate various aspects of the UPS or related stress responses, which can indirectly influence Fbxo12J activity by altering the cellular context in which it operates or by affecting the stability of proteins that interact with Fbxo12J.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that prevents degradation of ubiquitinated proteins, possibly affecting substrates of Fbxo12J. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Another proteasome inhibitor that can lead to the accumulation of Fbxo12J substrates by inhibiting their degradation. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Specifically inhibits the proteasome, which could result in reduced degradation of proteins ubiquitinated by Fbxo12J. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
An inhibitor of the ubiquitin-activating enzyme E1, which could reduce the ubiquitination activity of the SCF complex involving Fbxo12J. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
Inhibits the NEDD8-activating enzyme necessary for cullin neddylation, potentially affecting Fbxo12J's role in the SCF complex. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Disrupts MDM2-p53 interaction, which can lead to altered patterns of protein ubiquitination and degradation involving Fbxo12J. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
A selective proteasome inhibitor that could indirectly affect Fbxo12J by stabilizing its potential substrates. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Modulates heat shock proteins and can indirectly influence protein degradation pathways linked to Fbxo12J. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Modulates degradation of specific proteins by the proteasome and could affect those regulated by Fbxo12J. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
A steroidal lactone that can disrupt proteasomal activity, potentially leading to altered function of Fbxo12J. | ||||||