FBL11 Activators
FBL11, a key protein involved in chromatin remodeling and gene regulation, is modulated by various chemical compounds that influence specific signaling pathways and chromatin states. Parthenolide, by targeting NF-κB signaling, indirectly augments FBL11's histone demethylase activity, especially concerning H3K36 demethylation, a key process in chromatin organization and gene regulation. Disulfiram, through its inhibition of proteasome activity, may stabilize regulatory proteins that enhance FBL11 function, contributing to its role in gene expression regulation. Histone deacetylase inhibitors such as Trichostatin A and Suberoylanilide Hydroxamic Acid alter the chromatin landscape, potentially facilitating FBL11's action in modifying chromatin and regulating gene expression. This alteration to a more open chromatin state is critical for FBL11's function in the dynamic regulation of gene activity.
Additional compounds like 5-Azacytidine, through DNA methyltransferase inhibition, and Valproic Acid, another HDAC inhibitor, contribute to a chromatin environment conducive to FBL11's activity. These changes in the epigenetic landscape can result in enhanced expression or activity of FBL11, underlining its role in gene regulation. Lithium Chloride, by inhibiting GSK-3β and influencing Wnt signaling, along with PD 98059, a MEK inhibitor, and SB 431542, a TGF-β receptor inhibitor, further modulate pathways that impact gene expression and chromatin structure, indirectly enhancing FBL11's function. Retinoic Acid, all trans, known for its role in cell differentiation, also affects transcriptional regulation, potentially boosting FBL11's role in chromatin organization. Lastly, Rapamycin, by inhibiting mTOR, may create a cellular state that favors FBL11's involvement in chromatin remodeling and gene regulation. Together, these compounds, through diverse mechanisms, synergistically enhance the activity of FBL11, highlighting the intricate network of signaling pathways and chromatin dynamics that govern gene regulation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Targets NF-κB signaling, a pathway that can regulate histone modifications. Inhibiting NF-κB may indirectly enhance FBL11's histone demethylase activity, particularly in demethylating histone H3 lysine 36 (H3K36), crucial for chromatin organization and gene regulation. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Inhibits aldehyde dehydrogenase (ALDH) and proteasome activity. Disulfiram's proteasome inhibition could lead to the stabilization of regulatory proteins that enhance FBL11's function in chromatin remodeling and gene expression regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase (HDAC) inhibitor, it changes chromatin dynamics, potentially enhancing FBL11's role in histone modification and gene regulation by altering the chromatin landscape to a more open and accessible state. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can lead to demethylation and activation of certain genes. This may indirectly enhance FBL11 expression or activity by promoting a more transcriptionally active chromatin state. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
An HDAC inhibitor, Suberoylanilide Hydroxamic Acid alters chromatin structure and gene expression, potentially upregulating FBL11 expression or enhancing its functional activity in gene regulation and chromatin remodeling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β, leading to the stabilization and accumulation of β-catenin, which can influence Wnt signaling pathways. These pathways are implicated in the regulation of genes like FBL11, enhancing its role in chromatin remodeling and gene expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor that indirectly influences FBL11 by modulating signaling pathways related to gene expression and chromatin remodeling. This modulation can enhance FBL11's function in these processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits the TGF-β receptor, impacting TGF-β signaling pathways. This inhibition can indirectly enhance FBL11 expression and activity, as TGF-β signaling interacts with pathways regulating gene expression and chromatin structure where FBL11 is involved. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Influences gene expression and chromatin remodeling through its role in cell differentiation and development. Retinoic Acid, all trans can enhance FBL11's function by affecting the transcriptional regulation of genes involved in chromatin organization. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Functions as an HDAC inhibitor, affecting chromatin structure and gene expression. It may upregulate FBL11 expression or enhance its function in chromatin remodeling and gene regulation by altering chromatin accessibility. | ||||||