FAS, also known as CD95 or apoptosis antigen 1 (APO-1), is a cell surface receptor belonging to the tumor necrosis factor (TNF) receptor superfamily. It plays a pivotal role in the regulation of programmed cell death, a process known as apoptosis. The FAS receptor, upon binding with its natural ligand, FAS ligand (FASL), initiates a cascade of intracellular events that culminate in apoptosis. This receptor-ligand interaction is a crucial regulatory mechanism, ensuring cellular homeostasis by removing cells that are damaged, infected, or no longer needed. The downstream signaling of the FAS receptor involves the recruitment of several adaptor proteins and the formation of a death-inducing signaling complex (DISC), ultimately leading to the activation of caspases, the enzymes responsible for carrying out the apoptotic process.
FAS inhibitors are chemical compounds that modulate the activity of the FAS receptor, specifically aiming to hinder or prevent its ability to induce apoptosis. These inhibitors can operate at various levels, such as preventing the binding of FASL to the FAS receptor, blocking the recruitment or action of adaptor proteins, or directly targeting the downstream signaling molecules in the FAS-induced apoptotic pathway.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A is an immunosuppressive drug that can suppress the expression of FAS in T cells, thereby reducing apoptosis. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
This glucocorticoid can reduce the expression of FAS in certain cells, potentially limiting apoptosis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can decrease FAS expression in some cancer cells, contributing to its anti-cancer properties. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, can reduce FAS levels in specific cell types, suggesting a mechanism for its protective effects. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, may lead to decreased FAS expression, which could be part of its immunosuppressive action. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
As a specific inhibitor of MEK, PD98059 can reduce FAS expression in certain contexts. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that may decrease FAS levels, affecting apoptosis pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
By inhibiting JNK, SP600125 can lead to reduced FAS expression in some cells. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
This NF-kappaB inhibitor can reduce FAS expression, thereby influencing apoptosis pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
By inhibiting p38 MAPK, SB203580 might reduce FAS expression in certain cells. |