FAS Activators
FAS activators represent a diverse group of compounds that modulate the activity of Fatty Acid Synthase (FAS), a key enzyme involved in de novo fatty acid biosynthesis. Among the selected chemicals, A23187, Cerulenin, Betulinic Acid, GW7647, AICAR, C75, TOFA, Resveratrol, Soraphen A, Trimetazidine, A769662, and Exendin-4 have been identified as modulators of FAS. These activators exert their influence through both direct and indirect mechanisms. A23187, for instance, indirectly activates FAS by elevating intracellular calcium levels, which modulates calcium-dependent signaling pathways associated with FAS regulation. Cerulenin, on the other hand, indirectly impacts FAS activation by inhibiting fatty acid synthase (FASN), disrupting de novo fatty acid synthesis, and altering cellular processes associated with FAS function.
Betulinic Acid can activate FAS indirectly by disrupting mitochondrial function and promoting reactive oxygen species (ROS) production. This, in turn, triggers cellular stress responses that modulate FAS activity and influence lipid biosynthesis. GW7647, a PPARα agonist, indirectly activates FAS by influencing peroxisome proliferator-activated receptor alpha (PPARα) signaling, thereby impacting lipid metabolism and FAS-associated processes. AICAR, C75, TOFA, Resveratrol, Soraphen A, Trimetazidine, A769662, and Exendin-4 all indirectly influence FAS by modulating cellular energy status and lipid metabolism through activation of AMP-activated protein kinase (AMPK) or inhibition of acetyl-CoA carboxylase (ACC). These compounds, by impacting AMPK-mediated regulation, can influence the activity of FAS in lipid biosynthesis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that elevates intracellular calcium levels, indirectly influencing FAS activation by modulating calcium-dependent signaling pathways associated with FAS regulation. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin is an inhibitor of fatty acid synthase (FASN), indirectly impacting FAS activation by disrupting de novo fatty acid synthesis. This alteration in lipid metabolism can influence cellular processes associated with FAS function. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid can activate FAS indirectly by disrupting mitochondrial function and promoting reactive oxygen species (ROS) production, triggering cellular stress responses that modulate FAS activity. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
GW7647 is a PPARα agonist that can indirectly activate FAS by influencing peroxisome proliferator-activated receptor alpha (PPARα) signaling, subsequently impacting lipid metabolism and FAS-associated processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), indirectly influencing FAS by modulating cellular energy status and lipid metabolism. This AMPK-mediated regulation can impact the activity of FAS in lipid biosynthesis. | ||||||
C75 (racemic) | 191282-48-1 | sc-202511 sc-202511A sc-202511B | 1 mg 5 mg 10 mg | $72.00 $206.00 $290.00 | 9 | |
C75 is an inhibitor of fatty acid synthase (FASN), and paradoxically, it can activate FAS indirectly by disrupting the feedback inhibition of FAS, leading to the accumulation of malonyl-CoA and subsequent activation of FAS. | ||||||
TOFA (5-(Tetradecyloxy)-2-furoic acid) | 54857-86-2 | sc-200653 sc-200653A | 10 mg 50 mg | $97.00 $374.00 | 15 | |
TOFA inhibits acetyl-CoA carboxylase (ACC), indirectly influencing FAS by modulating fatty acid biosynthesis. This indirect modulation of lipid metabolism can affect FAS activity and cellular processes associated with lipid synthesis. | ||||||
Trimetazidine Dihydrochloride | 13171-25-0 | sc-220334 | 10 mg | $213.00 | ||
Trimetazidine indirectly activates FAS by modulating cellular energy metabolism and glucose utilization. This impact on energy status can influence the activation of FAS and its associated lipid biosynthetic processes. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator, indirectly influencing FAS by modulating cellular energy status and lipid metabolism. This AMPK-mediated regulation can impact the activity of FAS in lipid biosynthesis. | ||||||
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $146.00 $198.00 | 1 | |
Exendin-4 activates AMP-activated protein kinase (AMPK), indirectly influencing FAS by modulating cellular energy status and lipid metabolism. This AMPK-mediated regulation can impact the activity of FAS in lipid biosynthesis. | ||||||