FAM98C Activators
FAM98C employ various cellular mechanisms to modulate the activity of this protein. Forskolin, through its ability to activate adenylyl cyclase, increases intracellular cAMP levels, which in turn activate protein kinase A (PKA). PKA is a key regulator in the phosphorylation of many cellular targets, and this enzymatic action can lead to the activation of FAM98C. Similarly, 8-Br-cAMP, a cell-permeable analog of cAMP, directly stimulates PKA, potentially resulting in the phosphorylation and subsequent activation of FAM98C. Isoproterenol functions in a comparable manner; as a synthetic catecholamine, it binds to beta-adrenergic receptors, causing a surge in cAMP levels and thereby activating PKA, which can then target FAM98C.
PMA is known to activate protein kinase C (PKC), which phosphorylates a multitude of substrates within the cell, potentially including FAM98C. Ionomycin, by increasing intracellular calcium levels, can activate calcium-dependent protein kinases, which may also target FAM98C for activation. Insulin and Insulin-like Growth Factor 1 (IGF-1) both stimulate the PI3K/Akt signaling pathway, a crucial pathway for cell survival and metabolism, which could implicate the activation of FAM98C through downstream effects. Epidermal Growth Factor (EGF) triggers the EGFR tyrosine kinase and initiates a series of downstream signaling events, possibly leading to the modification and activation of FAM98C. Reactive molecules like Hydrogen Peroxide activate various kinases through oxidative stress-related pathways, potentially impacting the activation state of FAM98C. Anisomycin's role in activating stress-activated protein kinases (SAPKs) may similarly lead to FAM98C activation in response to cellular stress. Lastly, inhibitors of protein phosphatases such as Calyculin A and Okadaic Acid result in increased phosphorylation levels of cellular proteins, which can culminate in the activation of FAM98C due to reduced dephosphorylation activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate a variety of substrates that may be involved in the same signaling pathways as FAM98C, potentially leading to the functional activation of FAM98C. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases may phosphorylate and thus activate FAM98C or proteins that interact with FAM98C, leading to its functional activation. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cell-permeable cAMP analog that activates PKA. PKA activation may result in the phosphorylation and subsequent activation of FAM98C. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which can result in the activation of downstream proteins that may include FAM98C, given its potential role in cellular growth and metabolism. | ||||||
IGF-1R Inhibitor, PPP | 477-47-4 | sc-204008A sc-204008 sc-204008B | 1 mg 10 mg 100 mg | $138.00 $203.00 $895.00 | 63 | |
Insulin-like Growth Factor 1 (IGF-1) engages the IGF1 receptor to activate the PI3K/Akt and MAPK/ERK pathways, possibly resulting in the activation of FAM98C through these signaling cascades. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide serves as a signaling molecule that can lead to the activation of various kinases through oxidative stress pathways. These kinases could activate FAM98C by phosphorylation or by activating signaling cascades involving FAM98C. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs), such as JNK. Activation of these kinases could lead to the activation of FAM98C as part of the stress response. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), which may result in increased phosphorylation of proteins, potentially including FAM98C, therefore promoting its activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid inhibits protein phosphatases PP1 and PP2A, similar to Calyculin A, leading to increased phosphorylation and potential activation of FAM98C. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, leading to the activation of adenylyl cyclase and increased cAMP levels. This elevation can activate PKA, which may phosphorylate and activate FAM98C. | ||||||