FAM98C Inhibitors
FAM98C inhibitors encompass a range of compounds that influence various cellular signaling pathways and processes. LY294002 and Wortmannin are two such inhibitors that target the PI3K/AKT signaling pathway. By inhibiting PI3K, these compounds prevent the phosphorylation and subsequent activation of AKT, leading to a decrease in downstream signaling activities that may involve FAM98C. This reduced signaling can result in lower FAM98C activity if FAM98C's function is reliant on signals propagated through the AKT pathway.
In addition to the PI3K/AKT pathway, other compounds such as PD98059 and U0126 target the MAPK/ERK pathway by specifically inhibiting MEK1/2. This inhibition results in less activation of ERK, a kinase that could phosphorylate and regulate FAM98C.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor that prevents the phosphorylation and activation of AKT. FAM98C, if involved in cell survival and growth processes mediated by the PI3K/AKT pathway, would have reduced activity due to the lack of AKT signaling, which is essential for these processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that blocks the PI3K/AKT pathway. Inhibition of PI3K leads to decreased AKT activity, which is crucial for cell survival. If FAM98C's function is AKT-dependent, wortmannin would lead to a decrease in its functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an inhibitor of the mTOR complex, which is downstream of PI3K/AKT signaling. By inhibiting mTOR, rapamycin can suppress the cell growth and proliferation signals. If FAM98C operates downstream of mTOR, its activity would be decreased due to the suppression of this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that blocks the MAPK/ERK pathway. This pathway is involved in cell proliferation and differentiation. If FAM98C is implicated in these processes, its activity could be reduced by inhibiting MEK and subsequently the MAPK/ERK pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK signaling pathways. JNK is involved in controlling apoptosis and inflammation. If FAM98C is involved in these processes, its activity could be reduced by JNK inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, which is involved in the stress response. Inhibition of p38 MAPK would decrease FAM98C activity if FAM98C is part of the cellular response to stress and inflammation mediated by p38 MAPK. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor that impacts cell shape and motility by affecting the Rho/ROCK pathway. If FAM98C is involved in cellular mechanics governed by the Rho/ROCK pathway, its activity could be reduced by ROCK inhibition. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor, key regulators of mitosis. If FAM98C is involved in mitosis, its activity would be diminished due to the inhibition of Aurora kinases and the subsequent disruption of mitotic processes. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a CDK inhibitor that is important for cell cycle regulation. If FAM98C has a role in cell cycle progression, its activity could be indirectly decreased through the inhibition of CDKs by roscovitine. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib is a receptor tyrosine kinase inhibitor affecting multiple signaling pathways including those for proliferation and angiogenesis. If FAM98C functions within these pathways, sunitinib would lead to reduced FAM98C activity. | ||||||