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Rapamycin (CAS 53123-88-9)

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Alternate Names:
Rapamycin is also known as mTOR Inhibitor I.
Application:
Rapamycin acts as an allosteric inhibitor of mTOR and inhibits FRAP autophosphorylation, which leads to activation of the p70/85 S6 kinase.
CAS Number:
53123-88-9
Purity:
≥98%
Molecular Weight:
914.17
Molecular Formula:
C51H79NO13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Rapamycin is a FRAP inhibitor that exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities. The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. Rapamycin also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Rapamycin also exhibits Angiogenesis inhibition, possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR. Rapamycin is also known as Rapamune, 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, and mTOR Inhibitor I.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Rapamycin (CAS 53123-88-9) References

  1. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.  |  Chung, J., et al. 1992. Cell. 69: 1227-36. PMID: 1377606
  2. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase.  |  Price, DJ., et al. 1992. Science. 257: 973-7. PMID: 1380182
  3. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.  |  Phung, TL., et al. 2006. Cancer Cell. 10: 159-70. PMID: 16904613
  4. Inhibition of T and B lymphocyte proliferation by rapamycin.  |  Kay, JE., et al. 1991. Immunology. 72: 544-9. PMID: 1709916
  5. FK506 and rapamycin: novel pharmacological probes of the immune response.  |  Chang, JY., et al. 1991. Trends Pharmacol Sci. 12: 218-23. PMID: 1710854
  6. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.  |  Heitman, J., et al. 1991. Science. 253: 905-9. PMID: 1715094
  7. Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.  |  Arriola Apelo, SI. and Lamming, DW. 2016. J Gerontol A Biol Sci Med Sci. 71: 841-9. PMID: 27208895
  8. Rapamycin rejuvenates oral health in aging mice.  |  An, JY., et al. 2020. Elife. 9: PMID: 32342860
  9. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.  |  Sabatini, DM., et al. 1994. Cell. 78: 35-43. PMID: 7518356
  10. Control of p70 s6 kinase by kinase activity of FRAP in vivo.  |  Brown, EJ., et al. 1995. Nature. 377: 441-6. PMID: 7566123
  11. The rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol 4-kinase activity.  |  Sabatini, DM., et al. 1995. J Biol Chem. 270: 20875-8. PMID: 7673106
  12. Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.  |  Fingar, DC., et al. 1993. J Biol Chem. 268: 3005-8. PMID: 7679106
  13. A mammalian protein targeted by G1-arresting rapamycin-receptor complex.  |  Brown, EJ., et al. 1994. Nature. 369: 756-8. PMID: 8008069
  14. Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.  |  Morice, WG., et al. 1993. J Biol Chem. 268: 3734-8. PMID: 8429048
  15. [Pulmonary thromboembolism in autopsy material of the Department of Pathological Anatomy of the Warsaw Medical Academy].  |  Gawdzińska-Grabowska, H. 1977. Pol Tyg Lek. 32: 679-82. PMID: 866250

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Rapamycin, 1 mg

sc-3504
1 mg
$63.00

Rapamycin, 5 mg

sc-3504A
5 mg
$158.00

Rapamycin, 25 mg

sc-3504B
25 mg
$326.00