Molecular structure of IGF-1R Inhibitor, PPP, CAS Number: 477-47-4
IGF-1R Inhibitor, PPP (CAS 477-47-4)
See product citations (63)
Alternate Names:
IGF-1R Inhibitor, PPP is also known as Picropodophyllin.
Application:
IGF-1R Inhibitor, PPP is a non-competitive inhibitor of IGF-1R and apoptosis inducer, with antineoplastic activity.
CAS Number:
477-47-4
Purity:
≥96%
Molecular Weight:
414.40
Molecular Formula:
C22H22O8
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IGF-1R Inhibitor, PPP is an insulin-like, cell-permeable cis-cyclolignan compound that acts as a non-competitive, potent, and specific inhibitor of IGF-1Rα/β (growth factor-I receptor kinase - IC50 = 1 nM in cell-free kinase assay ≤ 60 nM for cell viability and receptor autophosphorylation in melanoma cell lines). IGF-1R Inhibitor, PPP exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. IGF-1R Inhibitor, PPP is the first inhibitor reported to discriminate between IGF-1R and IR, and has shown promising in vivo effects in SCID mice (complete inhibition of IGF-1R-dependent tumor cell growth at 20 mg/kg/12 hr i.p. in SCID mice) with minimum toxic effect (LD50 > 500 mg/kg). IGF-1R Inhibitor, PPP has an IC50 of 1 nM.
IGF-1R Inhibitor, PPP (CAS 477-47-4) References
- Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. | Girnita, A., et al. 2004. Cancer Res. 64: 236-42. PMID: 14729630
- IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. | Strömberg, T., et al. 2006. Blood. 107: 669-78. PMID: 16166596
- Activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochondrial respiratory stress. | Guha, M., et al. 2007. J Biol Chem. 282: 14536-46. PMID: 17355970
- Structure and in vitro replication of DNA templates containing 7,8-dihydro-8-oxoadenine. | Guschlbauer, W., et al. 1991. Nucleic Acids Res. 19: 1753-8. PMID: 1851559
- Determination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry. | Rönquist-Nii, Y., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 326-34. PMID: 21251888
- Picropodophyllin inhibits tumor growth of human nasopharyngeal carcinoma in a mouse model. | Yin, SC., et al. 2013. Biochem Biophys Res Commun. 439: 1-5. PMID: 23973483
- Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells. | Tomizawa, M., et al. 2014. Oncol Lett. 8: 2023-2026. PMID: 25289088
- Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cells. | Strömberg, T., et al. 2015. Med Oncol. 32: 188. PMID: 26021470
- Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo. | Tarnowski, M., et al. 2017. BMC Cancer. 17: 532. PMID: 28793874
- Picropodophyllin inhibits type I endometrial cancer cell proliferation via disruption of the PI3K/Akt pathway. | Dong, L., et al. 2019. Acta Biochim Biophys Sin (Shanghai). 51: 753-760. PMID: 31168597
- Rehmannia glutinosa Libosch Extracts Prevent Bone Loss and Architectural Deterioration and Enhance Osteoblastic Bone Formation by Regulating the IGF-1/PI3K/mTOR Pathway in Streptozotocin-Induced Diabetic Rats. | Gong, W., et al. 2019. Int J Mol Sci. 20: PMID: 31443143
- N-cadherin upregulation mediates adaptive radioresistance in glioblastoma. | Osuka, S., et al. 2021. J Clin Invest. 131: PMID: 33720050
- Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis. | Wang, L., et al. 2021. Cell Death Discov. 7: 251. PMID: 34537816
- Picropodophyllin inhibits the growth of pemetrexed-resistant malignant pleural mesothelioma via microtubule inhibition and IGF-1R-, caspase-independent pathways. | Sun, R., et al. 2022. Transl Lung Cancer Res. 11: 543-559. PMID: 35529797
- Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells via ROS Production and PI3K/AKT Pathway Inhibition. | Zhu, X., et al. 2022. Biol Pharm Bull. 45: 1027-1035. PMID: 35908886
Inhibitor of:
A2LD1, BZW1, IGF-I, IGF-IA, IGF-IB, IGF-II, IGF-IIR, IGF-IR, IGF-IRα, IGF-IRβ, IGF2AS, IGFBP4, IGFBPL1, IGFL2, Insulin II, and PCDGF.Activator of:
Arylsulfatase G, C2orf61, C9orf85, DAF-2, Dim2, EG626970, FAM98C, GRINA, LOC339229, LRRC29, LRRC36, PAPP-A, RUNDC3A, Sgk494, Vmn1r31, and ZNF215.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IGF-1R Inhibitor, PPP, 1 mg | sc-204008A | 1 mg | $138.00 | |||
IGF-1R Inhibitor, PPP, 10 mg | sc-204008 | 10 mg | $203.00 | |||
IGF-1R Inhibitor, PPP, 100 mg | sc-204008B | 100 mg | $895.00 |