FAM78A Activators

Epigallocatechin gallate and Resveratrol target cellular stress response and longevity pathways, respectively. EGCG enhances the body's antioxidant capabilities, potentially affecting the same oxidative conditions that regulate FAM78A, while Resveratrol's activation of SIRT1 could modify protein function in pathways where FAM78A is engaged. Curcumin brings about its effect by modulating the NF-κB pathway, a key regulator of immune response and cell survival, which in turn can affect gene expression in FAM78A's operational landscape. Sodium butyrate, affecting gene expression through its HDAC inhibitory activity, also has the capacity to modify the cellular context governing FAM78A's activity.

Lithium chloride and SB431542 take a different approach by targeting GSK-3β and TGF-β signaling, both of which can have downstream effects on cellular differentiation and proliferation processes that could encompass FAM78A's role. MEK-specific inhibitors such as PD98059 lead to changes in the MAPK/ERK pathway, while LY294002's inhibition of PI3K affects the AKT pathway, both central to cell signaling and potential FAM78A activity regulation. Rapamycin, an mTOR inhibitor, affects both protein synthesis and autophagy, processes intimately connected with FAM78A's function. KN-93's inhibition of CaMKII and Bisindolylmaleimide I's inhibition of PKC each alter calcium signaling and cellular responses to external stimuli which can modulate FAM78A. Dorsomorphin's inhibition of AMPK shifts cellular energy balance, reflecting changes in metabolic signaling that can activate FAM78A.