Date published: 2026-5-16

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FAM78A Inhibitors

FAM78A inhibitors are a class of chemical compounds that specifically target and inhibit the function of the FAM78A protein, a relatively lesser-known member of the FAM78 family. Although the exact biological role of FAM78A is not fully understood, this protein is thought to be involved in fundamental cellular processes, potentially related to intracellular signaling, cellular stress responses, or the maintenance of cellular homeostasis. FAM78A is expressed in various tissues, where it may interact with other proteins to influence cellular pathways that are critical for the proper functioning of cells. Inhibitors of FAM78A are designed to bind to specific sites on this protein, thereby blocking its activity and allowing researchers to investigate the consequences of its inhibition on cellular functions. The mechanism by which FAM78A inhibitors work typically involves the binding of these compounds to functional domains of the FAM78A protein, such as regions involved in protein-protein interactions or enzymatic activity, if applicable. This binding can prevent FAM78A from participating in its normal cellular roles, leading to disruptions in the pathways it regulates. For example, inhibition of FAM78A might alter cellular signaling cascades, affect the cell's ability to manage stress, or impact processes such as ion transport or energy metabolism. These inhibitors are valuable tools for exploring the specific biological functions of FAM78A, providing insights into how this protein contributes to the overall network of cellular activities. Understanding the effects of FAM78A inhibition is crucial for elucidating the broader role of the FAM78 family in cellular physiology and for uncovering the molecular mechanisms that govern cellular homeostasis and response to environmental changes.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

Inhibits PI3K, leading to reduced activity of downstream AKT signaling, which may regulate FAM78A.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

Inhibits MEK1/2, thereby disrupting the MAPK/ERK pathway that may control FAM78A activity or stability.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$82.00
$216.00
$416.00
48
(1)

Inhibits the TGF-β receptor, potentially altering SMAD signaling pathways that may modulate FAM78A.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

Inhibits MEK, which may influence the MAPK/ERK pathway and thus affect the function of FAM78A.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

Inhibits JNK, which may affect apoptosis and other cellular responses where FAM78A may play a role.

GW 5074

220904-83-6sc-200639
sc-200639A
5 mg
25 mg
$106.00
$417.00
10
(1)

Inhibits RAF-1 kinase, potentially disrupting the MAPK/ERK signaling axis that may involve FAM78A.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Inhibits mTOR, which may impact cell growth and proliferation pathways that FAM78A could be part of.

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$94.00
$227.00
30
(1)

Inhibits Src family kinases, which may modulate various signaling pathways including those related to FAM78A.

DAPT

208255-80-5sc-201315
sc-201315A
sc-201315B
sc-201315C
5 mg
25 mg
100 mg
1 g
$40.00
$120.00
$480.00
$2141.00
47
(3)

Inhibits γ-secretase, leading to reduced Notch signaling that may intersect with FAM78A's functional pathways.

IWP-2

686770-61-6sc-252928
sc-252928A
5 mg
25 mg
$96.00
$292.00
27
(1)

Inhibits Wnt production, which may affect Wnt signaling pathways and potentially the activity of FAM78A.