FAM76A Inhibitors
FAM76A Inhibitors encompass a variety of chemical compounds that, through distinct biochemical mechanisms, lead to the decreased functional activity of FAM76A. Histone deacetylase inhibitors like Trichostatin A modify chromatin structure and gene expression, potentially affecting genes that regulate FAM76A function. Similarly, 5-Azacytidine, by reducing DNA methylation, might activate the transcription of genes which suppress FAM76A. Proteasome inhibitors such as MG-132 and Bortezomib can cause the accumulation of proteins that negatively regulate FAM76A, thereby diminishing its activity. Certain kinase inhibitors, such as the broad-spectrum Staurosporine, disrupt multiple signaling pathways, which could include those that stabilize or activate FAM76A, resulting in its reduced function. The PI3K inhibitor LY 294002 and the mTOR inhibitor Rapamycin disrupt upstream signaling that may regulate theexpression or stability of FAM76A, leading to its diminished activity.
The functional inhibition of FAM76A is also mediated by compounds that interfere with the MAPK/ERK and JNK pathways, such as PD 98059, SP600125, and U0126. These inhibitors prevent the activation of kinases that could influence the transcription and stability of FAM76A or its regulatory proteins. Inhibition of protein synthesis through Cycloheximide further contributes to the reduction of FAM76A activity by decreasing the levels of interacting or regulatory proteins. The Hsp90 inhibitor 17-AAG disrupts the proper folding and stability of client proteins, which may include FAM76A itself or proteins that modulate its function. Collectively, these FAM76A inhibitors operate by targeting various cellular processes and signaling pathways to ultimately result in the decreased activity of FAM76A without directly binding to or altering the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that leads to hyperacetylation of histones, affecting chromatin structure and gene expression. It indirectly diminishes FAM76A function by altering the transcriptional landscape where FAM76A is implicated. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine leads to the hypomethylation of DNA, which can result in the transcriptional activation of genes that suppress FAM76A expression or function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially increasing the levels of proteins that negatively regulate FAM76A's function or stability. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 is a PI3K inhibitor that disrupts PI3K/Akt signaling. By inhibiting this pathway, downstream effects can lead to reduced expression or activity of proteins like FAM76A, which may be regulated by PI3K/Akt. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor which can lead to the downregulation of protein synthesis. By inhibiting mTOR, the synthesis of proteins that interact with or control the stability of FAM76A can be reduced, diminishing its functional activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent non-selective inhibitor of protein kinases. By broadly inhibiting kinases, it can diminish signaling pathways that stabilize or activate FAM76A, indirectly reducing its activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is another proteasome inhibitor that could lead to the accumulation of proteins that negatively regulate FAM76A's function, indirectly leading to its diminished activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 8059 is a MEK inhibitor that interferes with the MAPK/ERK pathway. By inhibiting MEK, the pathway's influence on the transcriptional regulation of genes, potentially including those affecting FAM76A function, can be diminished. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of the MAPK pathway. Inhibition of JNK could lead to reduced transcriptional activity of target genes that regulate FAM76A function, thus indirectly diminishing FAM76A's activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that blocks the MAPK/ERK pathway. Its inhibitory effect on MEK can lead to decreased regulation of genes involved in the stability or activity of FAM76A, indirectly leading to the protein's diminished functional activity. | ||||||