FAM58B Activators
FAM58B Activators are a group of chemical compounds that engage various cellular signaling pathways, resulting in the enhanced functional activity of FAM58B. Forskolin acts directly on adenylate cyclase, increasing cAMP levels within the cell, which in turn activates protein kinase A (PKA). PKA phosphorylates a broad spectrum of substrates, some of which may interact with FAM58B, leading to its enhanced activity. Similarly, Isoproterenol, a beta-adrenergic agonist, and Dibutyryl cAMP, a cAMP analog, also elevate intracellular cAMP levels, engaging PKA and thereby influencing FAM58B activity indirectly. IBMX contributes to this elevation of cAMP by inhibiting its degradation, further supporting PKA activation.
Additionally, pathways that involve calcium signaling can also indirectly impact FAM58B activity. Ionomycin, by increasing intracellular calcium levels, may potentiate the activity of calcium/calmodulin-dependent kinases that have substrates within the FAM58B pathway. Activation of protein kinase C (PKC) by Phorbol 12-myristate 13-acetate (PMA) could phosphorylate proteins that modulate FAM58B's activity. Growth factor pathways, exemplified by the action of Epidermal Growth Factor (EGF), activate the MAPK/ERK pathway, which could lead to downstream effects on FAM58B. Additionally, inhibitors such as LY294002 and U0126, which target the PI3K and MEK/ERK pathways respectively, alter the cellular signaling landscape, potentially affecting the regulation of proteins that interact with FAM58B. Y-27632, a ROCK inhibitor, may influence FAM58B activity by altering the dynamics of the actin cytoskeleton, impacting cellular structures with which FAM58B interacts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activator of protein kinase C (PKC) which can phosphorylate and alter the function of proteins within FAM58B's pathway, indirectly increasing FAM58B activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore, raises intracellular Ca2+ levels, potentially enhancing calcium/calmodulin-dependent protein kinase (CaMK) activity, which could phosphorylate proteins within the FAM58B pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Beta-adrenergic agonist that increases cAMP levels, thereby activating PKA which may enhance FAM58B activity through phosphorylation of associated proteins. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP, potentially enhancing PKA activity and the subsequent activation of FAM58B. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Activates stress-activated protein kinases, like JNK, which can modify the activity of proteins that regulate FAM58B's function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibitor of PI3K, altering the AKT signaling pathway, which may lead to changes in the activity of proteins that interact with FAM58B. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAP kinase, potentially affecting proteins that regulate FAM58B's activity through stress response pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibitor of ROCK, which modulates actin cytoskeleton dynamics, potentially affecting proteins that interact with FAM58B. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Analog of cAMP that can diffuse into cells and resist degradation, enhancing PKA activity and potentially the function of FAM58B through phosphorylation of regulatory proteins. | ||||||