FAM49A Activators
Epidermal growth factor (EGF) and insulin-like growth factor (IGF-1) engage with their respective receptor tyrosine kinases, initiating a cascade of intracellular signals that drive cell growth and survival, potentially altering protein functions. PMA directly stimulates protein kinase C (PKC), which is implicated in the regulation of numerous cellular functions. Isoproterenol operates through the beta-adrenergic pathway to increase cAMP levels, which in turn can activate protein kinase A (PKA), influencing protein activity and signaling.
Dibutyryl-cAMP, a synthetic mimic of cAMP, bypasses upstream receptors to directly activate PKA, leading to changes in protein phosphorylation and activity. Sodium orthovanadate acts as a phosphatase inhibitor, maintaining phosphorylation states that are crucial for the activation of many signaling proteins. The MAPK pathway, modulated by SB203580 and PD98059 through the selective inhibition of p38 MAPK and MEK, respectively, plays a critical role in cellular responses to external stress signals. LY294002, by inhibiting phosphoinositide 3-kinase (PI3K), disrupts the PI3K/AKT pathway, which is integral to cell growth and survival, while U0126 selectively blocks MEK1/2, affecting the MAPK/ERK pathway and consequently protein activity. Rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), can cause profound changes in cellular metabolism, protein synthesis, and autophagy, processes that are central to the regulation of protein function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Activates the insulin receptor pathway, influencing various cellular processes including protein synthesis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which can modulate numerous signaling pathways and potentially alter the activity of various proteins. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A beta-adrenergic agonist that increases cAMP levels, potentially activating PKA and affecting protein function. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog that can permeate cell membranes and activate PKA, potentially affecting protein activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Inhibits protein tyrosine phosphatases, potentially enhancing tyrosine phosphorylation-dependent signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that can modulate inflammatory response and cell differentiation pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of MEK, which can alter the MAPK/ERK pathway and potentially affect protein activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor, which can affect downstream AKT signaling and influence a wide range of cellular functions. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A selective inhibitor of MEK1/2, which can alter the MAPK/ERK signaling pathway, possibly affecting protein activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, which can impact protein synthesis and autophagy, potentially affecting protein levels and function. | ||||||