Fam48b1 Inhibitors
The chemical class referred to as Fam48b1 Inhibitors consists of a variety of compounds that impact transcription factor function by targeting different components of the transcriptional machinery and related cellular processes. These chemicals do not directly inhibit Fam48b1 but can indirectly affect its activity through various mechanisms. For example, Triptolide and Alpha-amanitin exert their effects by inhibiting RNA polymerase II, thereby suppressing overall mRNA synthesis, which includes the transcriptional outputs related to Fam48b1. Actinomycin D and DRB also target the transcriptional machinery, with Actinomycin D binding to DNA and DRB impeding transcriptional elongation, both of which can alter the transcriptional landscape that Fam48b1 engages with.
Additionally, the role of epigenetics in transcription factor function is targeted by compounds such as Trichostatin A and SAHA, which modify histone acetylation, potentially impacting the chromatin state and accessibility for Fam48b1. Small molecule inhibitors like ICG-001 and JQ1 interfere with signaling pathways and protein-protein interactions that are crucial for the regulation of transcription factor activity. ICG-001 disrupts the Wnt/β-catenin pathway, while JQ1 affects the binding of BET bromodomain proteins to chromatin, both of which can modulate the transcriptional programs involving Fam48b1. MG132, a proteasome inhibitor, can lead to the accumulation of regulatory proteins that influence the activity of transcription factors, and Curcumin modulates various signaling pathways, including those that affect transcription factor activity. C646 and SGC-CBP30 are more targeted in their approach, with C646 inhibiting the p300 histone acetyltransferase enzyme and SGC-CBP30 inhibiting BET bromodomain proteins, both altering the epigenetic landscape and, hence, the function of transcription factors like Fam48b1. Each of these chemicals interferes with the cellular and molecular pathways that are necessary for Fam48b1 to exert its effects on gene expression.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Inhibits general transcription by affecting RNA polymerase II activity, which can indirectly inhibit Fam48b1 activity. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Specifically inhibits RNA polymerase II, leading to downregulation of mRNA synthesis that can affect Fam48b1 function. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA and prevents RNA synthesis by inhibiting RNA polymerase, indirectly affecting Fam48b1. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits RNA polymerase II transcriptional elongation, which can reduce the expression of Fam48b1 target genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Inhibits histone deacetylases (HDACs), causing changes in chromatin structure that can alter Fam48b1 activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another HDAC inhibitor that leads to hyperacetylation of histones, potentially affecting Fam48b1 binding to chromatin. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that can lead to increased levels of proteins that regulate transcription factors, affecting Fam48b1 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Modulates transcription factors and inhibits NF-kB signaling, which can alter Fam48b1 function indirectly. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
Displaces BET bromodomains proteins from chromatin, potentially affecting the function of associated transcription factors like Fam48b1. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
A competitive inhibitor of p300 histone acetyltransferase, potentially affecting acetylation levels of histones and Fam48b1 activity. | ||||||