Fam48b1 Activators
Family with sequence similarity 48, member B1 activators encompass a variety of compounds that either increase intracellular second messengers, modulate kinase and phosphatase activities, or perturb signaling pathways to indirectly enhance the activity of Family with sequence similarity 48, member B1. Forskolin, by elevating cAMP levels, activates PKA, which is known to phosphorylate a multitude of proteins. Phosphorylation can change the conformation, localization, or interaction partners of proteins, thus affecting the signaling pathways in which Family with sequence similarity 48, member B1 is involved. Similarly, PMA activates PKC, which can phosphorylate substrates that interact with or regulate Family with sequence similarity 48, member B1, enhancing its activity.
The alterationof cellular phosphorylation states by compounds like Okadaic acid and Calyculin A, through the inhibition of protein phosphatases, ensures that proteins within the Family with sequence similarity 48, member B1 signaling network remain phosphorylated. This persistent phosphorylation can lead to an enhancement of Family with sequence similarity 48, member B1 activity. Compounds such as LY294002 and U0126, which inhibit key enzymes in the PI3K and MAPK pathways, can create a shift in cellular signaling dynamics. This shift may upregulate compensatory pathways or change the activity of proteins that directly interact with Family with sequence similarity 48, member B1, leading to its enhanced activity. Ionomycin raises intracellular calcium levels, which triggers the activation of calcium-dependent kinases capable of modulating the activity of proteins that are part of Family with sequence similarity 48, member B1's signaling network. This modulation is another route through which Family with sequence similarity 48, member B1 activity is enhanced. KN-93's inhibition of CaMKII can similarly result in the activation of other kinases or signaling molecules that compensate for the loss of CaMKII activity, potentially enhancing the activity of Family with sequence similarity 48, member B1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of proteins that are part of the signaling cascade where Family with sequence similarity 48, member B1 is involved. This can enhance its activity by altering its interaction with other proteins or its localization within the cell. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Elevated calcium can activate calcium-dependent protein kinases, which then can promote the activity of Family with sequence similarity 48, member B1 by phosphorylating proteins in its signaling network. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
As a cAMP analog, 8-Bromo-cAMP mimics the action of cAMP and activates PKA. This activation can lead to the enhanced activity of Family with sequence similarity 48, member B1 by PKA-mediated phosphorylation of proteins in its signaling pathway. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of cellular proteins. This can result in the enhanced activity of Family with sequence similarity 48, member B1 due to reduced dephosphorylation of proteins in its signaling pathway. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin acts as a protein synthesis inhibitor that also activates stress-activated protein kinases such as JNK. The activation of JNK can enhance the activity of Family with sequence similarity 48, member B1 by phosphorylation of proteins within its signaling network. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can increase the activity of downstream effectors by preventing their inhibition. This indirect effect can enhance the activity of Family with sequence similarity 48, member B1 by influencing the proteins that interact with or regulate its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, which can lead to an altered balance of kinase and phosphatase activities affecting the proteins that Family with sequence similarity 48, member B1 interacts with, thereby enhancing its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. By modulating this pathway, U0126 can lead to changes in the phosphorylation state of proteins that affect the activity of Family with sequence similarity 48, member B1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can prevent the phosphorylation of specific proteins, potentially altering signaling pathways and enhancing the activity of Family with sequence similarity 48, member B1 by affecting the proteins it interacts with. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, similar to okadaic acid. It leads to increased phosphorylation of proteins, which could enhance the functional activity of Family with sequence similarity 48, member B1 through this post-translational modification. | ||||||