FAM20C Activators
FAM20C, also known as the Golgi casein kinase, is an atypical protein kinase that phosphorylates secretory pathway proteins within the Golgi apparatus. As a kinase, FAM20C plays a crucial role in the regulation of biomineralization processes and the phosphorylation of various proteins involved in enamel formation, among other functions.
FAM20C activators might operate through a direct mechanism by binding to the kinase domain of FAM20C, thereby stabilizing the active conformation of the enzyme or enhancing its affinity for ATP and specific substrates. These activators could also mimic the effects of physiological activators or overcome inhibitory mechanisms that reduce FAM20C kinase activity, leading to increased phosphorylation of its target substrates. Alternatively, indirect activators of FAM20C could function by upregulating the expression of the FAM20C gene, leading to increased protein synthesis and greater enzymatic activity within cells. They might also affect the post-translational modifications of FAM20C, such as glycosylation patterns or proteolytic processing, which can modulate its activity or stability. Other indirect mechanisms could involve the modulation of signaling pathways that regulate the localization or function of FAM20C within the Golgi apparatus, thus affecting its overall activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP serves as a direct activator for FAM20C, as it is necessary for its kinase activity. ATP provides the phosphate groups that FAM20C transfers to its substrate proteins. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium ions are necessary for ATP binding and kinase activity of FAM20C. In the reaction catalyzed by FAM20C, magnesium ions form a complex with ATP, facilitating its binding to FAM20C and subsequent phosphate transfer. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate can indirectly activate FAM20C by inhibiting protein tyrosine phosphatases, which might dephosphorylate and inactivate FAM20C. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid indirectly activates FAM20C by inhibiting protein phosphatases PP1 and PP2A, which can dephosphorylate and inactivate FAM20C. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine can increase cAMP levels through the activation of beta-adrenergic receptors, which indirectly activates FAM20C via PKA. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic receptor agonist that can increase cAMP levels, indirectly activating FAM20C via PKA. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, enzymes that degrade cAMP. By maintaining cAMP levels, IBMX can indirectly activate FAM20C via PKA. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram selectively inhibits phosphodiesterase 4, resulting in increased cAMP levels, indirectly activating FAM20C via PKA. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog. By increasing cAMP levels, db-cAMP can indirectly activate FAM20C via PKA. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that can increase FAM20C expression, indirectly activating the protein by increasing its availability in the cell. | ||||||