FAM159A Inhibitors
SHISAL2A, identified as a predicted integral component of the membrane, represents a gene with implications for cellular organization and structure within Homo sapiens. Also known as FAM159A, PRO7171, and WWLS2783, this gene's predicted role suggests involvement in critical cellular processes associated with the cellular membrane. Despite its molecular intricacies not being fully elucidated, the integral nature of SHISAL2A within the membrane points to potential contributions in membrane dynamics, cellular structure, or signaling pathways vital for maintaining cell homeostasis. Its diverse nomenclature as FAM159A and the aliases PRO7171 and WWLS2783 emphasizes the gene's significance and potentially multifaceted functions in cellular biology.
The inhibition of SHISAL2A involves a strategic approach targeting interconnected signaling pathways and cellular processes. Various inhibitors impact distinct pathways such as PI3K-AKT, NF-κB, endocytosis, JNK, and mTOR, providing indirect influences on SHISAL2A expression and function. For instance, inhibitors like Wortmannin disrupt the PI3K-AKT axis, leading to downstream alterations in SHISAL2A-related processes, potentially influencing its role as an integral membrane component. Similarly, BAY 11-7082, an NF-κB inhibitor, impedes inflammatory responses, indirectly influencing SHISAL2A by targeting the NF-κB pathway. The identification of these inhibitors sheds light on potential regulatory networks governing SHISAL2A, offering insights into its functional roles within cellular membranes and the associated signaling cascades. Understanding the diverse pathways impacted by these inhibitors provides a foundation for further exploration of SHISAL2A's contributions to cellular processes, highlighting its intricate involvement in membrane dynamics and cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Golgi disruptor inhibiting vesicle formation and secretion. By targeting the secretory pathway, Brefeldin A indirectly impairs SHISAL2A, potentially disrupting its membrane integration and altering cellular processes associated with this integral component. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor disrupting the PI3K-AKT signaling axis. Wortmannin indirectly downregulates SHISAL2A expression and function by hindering the PI3K-associated cellular responses crucial for the integration of this predicted membrane component. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
NF-κB inhibitor impeding inflammatory responses. BAY 11-7082 indirectly influences SHISAL2A by targeting the NF-κB pathway, which may affect the gene's function as an integral membrane component, providing a potential avenue for its indirect inhibition. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $68.00 | 30 | |
PPARγ inhibitor impacting adipocyte differentiation. By blocking PPARγ, GW9662 indirectly interferes with SHISAL2A, as PPARγ modulation may influence cellular processes connected to the predicted membrane integration of this gene. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynamin inhibitor disrupting endocytosis. Dynasore indirectly influences SHISAL2A by perturbing endocytic processes, potentially impacting the membrane integration dynamics of this predicted integral component and modulating its cellular functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibitor of PI3K/AKT pathway, influencing SHISAL2A indirectly. LY294002 disrupts the PI3K-AKT axis, leading to downstream alterations in SHISAL2A-related processes, ultimately impeding the gene's expression and functional outcomes within cellular contexts. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
HSP90 inhibitor affecting protein folding. By targeting HSP90, 17-AAG indirectly influences SHISAL2A, potentially disrupting the proper folding and integration of this predicted integral membrane component within cellular membranes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
JNK inhibitor affecting SHISAL2A indirectly. SP600125 disrupts JNK-regulated pathways, leading to downstream alterations in SHISAL2A-related processes, ultimately impeding the gene's expression and functional outcomes within cellular contexts. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibitor of MEK/ERK pathway, indirectly impacting SHISAL2A. PD98059 disrupts the MEK/ERK pathway, leading to downstream alterations in SHISAL2A-related processes, ultimately impeding the gene's expression and functional outcomes within cellular contexts. | ||||||
BAY 11-7085 | 196309-76-9 | sc-202490 sc-202490A | 10 mg 50 mg | $122.00 $516.00 | 55 | |
Inhibitor of NF-κB activation, influencing SHISAL2A indirectly. Bay 11-7085 targets the NF-κB pathway, leading to downstream alterations in SHISAL2A-related processes, ultimately impeding the gene's expression and functional outcomes within cellular contexts. | ||||||