FAM159A Activators
SHISAL2A, also known as FAM159A, PRO7171, and WWLS2783, is a gene predicted to be an integral component of the membrane in Homo sapiens (human). Despite its potential importance in cellular membrane functions, the exact role and regulation of SHISAL2A remain to be fully elucidated. The activation of SHISAL2A can be a complex process, as direct activators are not well-defined. However, several chemicals can potentially influence SHISAL2A expression indirectly. Retinoic acid, for example, binds to nuclear receptors and regulates genes related to membrane integrity and differentiation, potentially affecting SHISAL2A expression. Forskolin, through cAMP-mediated signaling, can modulate phosphorylation states of membrane-associated proteins, indirectly impacting SHISAL2A. Epidermal Growth Factor (EGF) activates signaling cascades that affect membrane protein turnover and cell proliferation, potentially enhancing SHISAL2A expression. Additionally, compounds like sodium butyrate can influence epigenetic regulation, altering chromatin structure and accessibility to the SHISAL2A promoter region.
Lithium chloride, while not directly affecting Wnt ligands, can activate downstream targets of the Wnt signaling pathway that may indirectly influence membrane proteins and thereby affect SHISAL2A. Insulin, through PI3K/Akt pathways, can modulate membrane transporters and lipid metabolism, potentially impacting SHISAL2A expression. These examples highlight the diverse mechanisms by which various chemicals can indirectly activate SHISAL2A. In summary, SHISAL2A's function as an integral membrane component in humans suggests its involvement in critical cellular processes. The activation of SHISAL2A can be influenced by a range of chemicals that modulate various pathways related to membrane integrity, differentiation, and cellular proliferation. While direct activators are not yet defined, these indirect mechanisms shed light on potential regulatory pathways that govern SHISAL2A expression and function. Further research is needed to fully unravel the intricacies of SHISAL2A's role in cellular biology and its precise activation mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, binds to nuclear receptors, influencing gene expression. It may indirectly stimulate SHISAL2A expression by regulating genes involved in membrane integrity and cellular differentiation pathways. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin signaling activates PI3K/Akt pathways, impacting membrane transporters and lipid metabolism. This activation might indirectly upregulate SHISAL2A by modulating cellular processes that affect membrane composition and integrity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, can influence epigenetic regulation. It may indirectly stimulate SHISAL2A expression by altering chromatin structure and accessibility to the gene's promoter region. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates GSK-3β, a key kinase in the Wnt signaling pathway. While Wnt ligands are excluded per your instructions, downstream targets of Wnt signaling, including membrane proteins, may be indirectly influenced by lithium chloride and thereby affect SHISAL2A. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Vitamin A, a precursor of retinoic acid, can be converted intracellularly. It may indirectly stimulate SHISAL2A by serving as a source for retinoic acid synthesis, which, as mentioned earlier, can influence membrane integrity and differentiation processes. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels. Increased calcium levels can activate various signaling pathways, potentially influencing membrane protein expression. Ionomycin may indirectly upregulate SHISAL2A through calcium-dependent pathways. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyric acid, a short-chain fatty acid, can affect histone acetylation and gene expression. It may indirectly stimulate SHISAL2A expression by modifying chromatin structure, making the gene more accessible for transcription, and influencing membrane-related processes. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic Acid, also known as Vitamin B3, can activate GPR109A, affecting cellular metabolism. This activation might indirectly upregulate SHISAL2A by influencing membrane composition and integrity through changes in lipid metabolism and cellular processes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid sodium salt is a histone deacetylase inhibitor that can alter epigenetic regulation. It may indirectly stimulate SHISAL2A expression by modulating chromatin structure and accessibility to the gene's promoter region, potentially affecting membrane-related processes. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside, a precursor of NAD+, can activate sirtuins, influencing cellular metabolism. This activation might indirectly upregulate SHISAL2A by affecting membrane composition and integrity through changes in energy metabolism and cellular processes. | ||||||