FAM128B Activators
FAM128B (Mitotic Spindle Organizing Protein 2B) Activators, as a class of chemical compounds, play a pivotal role in regulating cell division, particularly during the process of mitosis. These activators are specifically designed to modulate the activity of the FAM128B protein, which is also known as mitotic spindle organizing protein 2B. FAM128B itself is a critical component of the mitotic spindle, a dynamic structure responsible for segregating chromosomes during cell division. Activators of FAM128B are meticulously crafted molecules that aim to enhance the functionality of this protein, ultimately ensuring the fidelity of chromosome segregation during mitosis.
The FAM128B activators work by directly interacting with the FAM128B protein, which is primarily located at the centrosomes, the microtubule-organizing centers of the cell. These activators exert their influence by fine-tuning the activity of FAM128B, thereby promoting the efficient assembly and organization of the mitotic spindle. This precise control over the spindle formation is essential for the accurate distribution of genetic material to daughter cells, preventing genetic instability and aneuploidy. While the detailed mechanisms of action for FAM128B activators may vary, their common objective is to promote the stability and efficiency of the mitotic spindle, contributing to the fundamental process of cell division.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Indirectly activates FAM128B by promoting stable microtubules, crucial for proper spindle organization during cell division. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Indirectly increases FAM128B activity by stabilizing microtubules, contributing to mitotic spindle organization. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
Indirectly activates FAM128B by modulating the MEK/ERK pathway, a key regulator of cell division and spindle organization. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Indirectly activates FAM128B-related processes by inhibiting TGF-β receptor signaling, influencing upstream events in cell division. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
Directly activates FAM128B by inhibiting Plk1, a kinase involved in spindle organization during cell division. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Indirectly activates FAM128B by modulating CDK activity, pivotal in cell cycle progression and spindle assembly. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
Indirectly activates FAM128B-related processes by modulating the Wnt signaling pathway, associated with cell division and spindle regulation. | ||||||
VX-11e | 896720-20-0 | sc-507301 | 10 mg | $180.00 | ||
Indirectly activates FAM128B by inhibiting Aurora kinases, a family involved in mitosis and spindle organization. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Indirectly activates FAM128B by directly disrupting microtubules, disturbing proper mitotic spindle organization. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
Indirectly activates FAM128B by inhibiting CHK1, a kinase that regulates the cell cycle and mitosis. | ||||||