FAM128B Inhibitors
FAM128B Inhibitors belong to a distinct chemical class designed to target and modulate the activity of the FAM128B protein. FAM128B, also known as CCDC88B or DAPLE (Dishevelled-associating protein with a high frequency of leucine residues), is a protein encoded by the FAM128B gene in humans. It is primarily associated with cellular signaling pathways, particularly those involving the Wnt signaling cascade. Wnt signaling plays a crucial role in various biological processes, including embryonic development, tissue homeostasis, and cell proliferation. The FAM128B protein acts as a key mediator within this pathway, facilitating interactions with Dishevelled (Dvl) proteins and contributing to the transduction of Wnt signals across the cell membrane.
FAM128B Inhibitors stems from a desire to selectively modulate the activity of FAM128B, offering a tool to probe the intricacies of Wnt signaling and its downstream effects. These inhibitors typically function by binding to specific sites on the FAM128B protein, disrupting its interactions with other signaling components and consequently altering the cellular responses mediated by Wnt signaling. Researchers are keenly exploring the structural and mechanistic aspects of FAM128B Inhibitors to enhance their specificity and efficacy, providing valuable insights into the regulation of Wnt signaling in diverse cellular contexts
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a non-selective protein kinase inhibitor that can affect a wide range of kinases, potentially altering phosphorylation states and functions of various proteins including kinases that might regulate FAM128B. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide acts to inhibit protein synthesis by interfering with the translocation step in protein synthesis, thus potentially decreasing the overall levels of proteins, including FAM128B. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can prevent the degradation of proteins, possibly leading to increased levels or altered function of proteins including those that interact with FAM128B. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that can modulate cellular growth and proliferation pathways, potentially affecting proteins that are regulated by or interact with FAM128B. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which can disrupt PI3K/Akt signaling pathways, potentially influencing the function or stability of a range of proteins including FAM128B. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that can interfere with the MAPK/ERK pathway, potentially modifying the activity of proteins regulated by or associated with FAM128B. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that can affect the JNK signaling pathway, potentially altering the function of proteins that are involved in the same pathway as FAM128B. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that could impact cellular stress responses and inflammation pathways, possibly affecting proteins in the same pathway as FAM128B. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that can alter cellular signaling pathways, potentially affecting the activity or stability of proteins like FAM128B. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor used to block the degradation of proteins, which could lead to altered function of proteins that may interact with FAM128B. | ||||||