FAM127A Activators
FAM127A activators consist of compounds that enhance the protein's activity by influencing various intracellular signaling pathways that either phosphorylate FAM127A or modify the activity of proteins within FAM127A's regulatory network. Forskolin and Rolipram, through the elevation of cAMP levels, activate PKA, which may directly phosphorylate FAM127A or phosphorylate key proteins that interact with FAM127A, leading to its enhanced functional activity. Similarly, Sildenafil and Zaprinast bolster cGMP levels, engaging cGMP-dependent protein kinases that may phosphorylate FAM127A or proteins within its signaling pathway, facilitating FAM127A's activation. PMA, as a PKC activator, and Epigallocatechin gallate, as a kinase inhibitor, could act by directly or indirectly phosphorylating proteins that regulate FAM127A's function, thereby augmenting its activity.
Conversely, the use of kinase inhibitors such as LY294002, SB203580, and U0126 might shift cellular signaling equilibriums, leading to an upregulation of pathways that enhance FAM127A
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P binds to its G protein-coupled receptors, initiating a signaling cascade that can lead to the activation of phospholipase C and the release of calcium ions. This increase in intracellular calcium may activate downstream proteins such as FAM127A. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, activating calcium-dependent kinases and phosphatases that could be involved in the phosphorylation state and thus activation of FAM127A. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is implicated in various signaling pathways. The activation of PKC could lead to phosphorylation and consequent activation of FAM127A if it is part of a pathway regulated by PKC. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a tyrosine kinase inhibitor that could prevent the phosphorylation of proteins that may otherwise inhibit the function of FAM127A, thus indirectly enhancing its activity by removing inhibitory signals. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that could block signaling pathways negatively regulating FAM127A, potentially resulting in its enhanced activity through the relief of inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that may shift signaling from p38 MAPK pathways to others, potentially leading to the activation of FAM127A if it is part of or regulated by alternative pathways. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1 receptors which can lead to calcium influx and activation of calcium-dependent signaling cascades, potentially affecting the activity of FAM127A. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuins, which are implicated in deacetylation of proteins. Sirtuin activation could modify the acetylation state of FAM127A, potentially enhancing its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, potentially reducing the expression of proteins that negatively regulate FAM127A, thereby indirectly increasing FAM127A activity. | ||||||