EXOSC4 Activators
OSC4, short for Exosome Component 4, Activators, is a chemical class that plays a pivotal role in regulating cellular processes by modulating the activity of EXOSC4, a vital component of the exosome complex. The exosome is an essential cellular machinery responsible for RNA processing, degradation, and quality control. EXOSC4, one of the key subunits in the exosome complex, is responsible for the stabilization of this macromolecular assembly, aiding in RNA degradation and surveillance. EXOSC4 activators are small molecules or compounds that interact with EXOSC4 to enhance its functional capabilities.
The exosome complex, which includes EXOSC4, is involved in various RNA processing pathways, such as mRNA turnover, ribosomal RNA processing, and the removal of defective RNA molecules. EXOSC4 activators can modulate these processes by increasing the stability of the exosome complex and its RNA processing efficiency. By binding to EXOSC4, these activators can potentially fine-tune the RNA processing and degradation pathways within the cell, ensuring the maintenance of RNA quality and quantity. This regulation can have far-reaching consequences for gene expression, cellular homeostasis, and response to environmental stressors. In essence, EXOSC4 activators represent a chemical class that holds promise in elucidating the intricacies of RNA biology and its fundamental role in cellular physiology. Further research into these activators could provide valuable insights into the mechanisms of RNA regulation and open new avenues for potential applications in various biological and biotechnological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that indirectly activates alterations in mRNA stability and translation, potentially activating changes in the RNA processing activities of EXOSC4. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that indirectly initiates shifts in gene expression patterns, thus activating changes in the types and quantity of RNA transcripts available for EXOSC4 activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An HDAC inhibitor that indirectly instigates shifts in chromatin structure, ultimately activating changes in gene expression and the RNA substrates processed by EXOSC4. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that indirectly triggers shifts in RNA metabolism by altering protein turnover, potentially activating changes in the pool of RNA molecules subject to EXOSC4 activity. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
An ATP synthase inhibitor that disrupts ATP production, indirectly activating changes in energy-dependent processes, which could activate alterations in EXOSC4's function in RNA metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
A compound that elevates cAMP levels, indirectly activating various cellular processes, including those that activate the regulation of RNA stability and turnover by EXOSC4. | ||||||
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $120.00 $215.00 | 2 | |
An inhibitor of p53-MDM2 interaction, modulating p53 activity, which indirectly activates changes in gene expression and the RNA substrates subject to EXOSC4 activation. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
An inhibitor of Wnt signaling that indirectly activates shifts in gene expression, potentially activating the RNA molecules available for processing by EXOSC4. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
An NF-κB inhibitor that indirectly triggers shifts in gene expression and RNA stability, which may subsequently activate the RNA substrates processed by EXOSC4. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
A γ-secretase inhibitor that indirectly modulates the Notch signaling pathway, potentially activating gene regulation and the RNA substrates subject to processing by EXOSC4. | ||||||