EXOSC4 Antibody (G-9): sc-166772
- EXOSC4 Antibody (G-9) is a mouse monoclonal IgG2a κ EXOSC4 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 2-243 of EXOSC4 of human origin
- EXOSC4 Antibody (G-9) is recommended for detection of EXOSC4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-EXOSC4 Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for EXOSC4 Antibody (G-9) for WB applications. These reagents are now offered in bundles with EXOSC4 Antibody (G-9) (see ordering information below).
EXOSC4 Antibody (G-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects EXOSC4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EXOSC4 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EXOSC4 protein, also known as exosome component 4, SKI6, RRP41, or p12A, is a crucial 245 amino acid component of the exosome complex, which plays a vital role in RNA metabolism by degrading unstable mRNAs containing AU-rich elements in untranslated regions. EXOSC4 is localized in both nucleus and cytoplasm, where EXOSC4 exhibits 3′-5′ exonuclease activity, essential for processing 7S pre-RNA into mature 5.8S rRNA. EXOSC4′s importance lies in maintaining RNA stability and regulating gene expression, which are critical for cellular homeostasis and response to environmental changes. EXOSC4 gene is located on human chromosome 8, a region associated with various diseases and malignancies, highlighting potential implications in health and disease. With high sequence identity to mouse counterpart, anti-EXOSC4 antibody (G-9) serves as a reliable tool for researchers studying RNA processing and exosome complex across different species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EXOSC4 Antibody (G-9) References:
- The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. | Allmang, C., et al. 1999. Genes Dev. 13: 2148-58. PMID: 10465791
- Three novel components of the human exosome. | Brouwer, R., et al. 2001. J Biol Chem. 276: 6177-84. PMID: 11110791
- AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. | Chen, CY., et al. 2001. Cell. 107: 451-64. PMID: 11719186
- Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. | Lejeune, F., et al. 2003. Mol Cell. 12: 675-87. PMID: 14527413
- The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA. | Guo, X., et al. 2007. Proc Natl Acad Sci U S A. 104: 151-6. PMID: 17185417
- Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. | van Dijk, EL., et al. 2007. RNA. 13: 1027-35. PMID: 17545563
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EXOSC4 Antibody (G-9) | sc-166772 | 200 µg/ml | $322.00 | |||
EXOSC4 Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-529045 | 200 µg Ab; 10 µg BP | $361.00 | |||
EXOSC4 Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-521739 | 200 µg Ab, 40 µg BP | $361.00 | |||
EXOSC4 Antibody (G-9): m-IgG2a BP-HRP Bundle | sc-547244 | 200 µg Ab; 10 µg BP | $361.00 | |||
EXOSC4 Antibody (G-9) AC | sc-166772 AC | 500 µg/ml, 25% agarose | $424.00 | |||
EXOSC4 Antibody (G-9) HRP | sc-166772 HRP | 200 µg/ml | $322.00 | |||
EXOSC4 Antibody (G-9) FITC | sc-166772 FITC | 200 µg/ml | $336.00 | |||
EXOSC4 Antibody (G-9) PE | sc-166772 PE | 200 µg/ml | $349.00 | |||
EXOSC4 Antibody (G-9) Alexa Fluor® 488 | sc-166772 AF488 | 200 µg/ml | $364.00 | |||
EXOSC4 Antibody (G-9) Alexa Fluor® 546 | sc-166772 AF546 | 200 µg/ml | $364.00 | |||
EXOSC4 Antibody (G-9) Alexa Fluor® 594 | sc-166772 AF594 | 200 µg/ml | $364.00 | |||
EXOSC4 Antibody (G-9) Alexa Fluor® 647 | sc-166772 AF647 | 200 µg/ml | $364.00 | |||
EXOSC4 Antibody (G-9) Alexa Fluor® 680 | sc-166772 AF680 | 200 µg/ml | $364.00 | |||
EXOSC4 Antibody (G-9) Alexa Fluor® 790 | sc-166772 AF790 | 200 µg/ml | $364.00 |