EVI27 Activators
EVI27 Activators encompass a spectrum of chemical entities that directly or indirectly catalyze the activation of EVI27 through specific intracellular signaling cascades. Forskolin, Isoproterenol, Rolipram, and IBMX augment intracellular cyclic AMP (cAMP) levels via distinct mechanisms including direct adenylyl cyclase stimulation, beta-adrenergic receptor engagement, selective phosphodiesterase 4 inhibition, and broad phosphodiesterase inhibition, respectively. The resultant elevation in cAMP triggers protein kinase A (PKA) activation, which is likely to phosphorylate and thereby enhance the activity of EVI27. Concurrently, other compounds such as Epigallocatechin gallate (EGCG) and Anisomycin modulate cellular signaling by inhibiting various protein kinases and activating stress-activated protein kinases (SAPKs) pathways, respectively, which can lead to the activation of transcription factors and kinases that enhance EVI27's functional role.
In parallel, the biochemical landscape of EVI27 activation is further diversified by compounds that alter intracellular ion concentrations. Ionomycin and A23187 (Calcimycin) elevate intracellular calcium levels, engaging calcium-dependent signaling mechanisms that could potentiate EVI27 activity. Furthermore, Sphingosine-1-phosphate, through its interaction with sphingosine-1-phosphate receptors, triggers downstream signaling cascades that may incorporate EVI27 activation. The cumulative effect of these chemical activators, from cAMP modulation to kinase regulation and ion concentration alterations, provides a multifaceted framework for enhancing the functional activity of EVI27 without necessitating increased gene expression or direct activation of the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate specific substrates that may include EVI27, leading to its activation or enhancement of its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC has been implicated in the regulation of a variety of proteins through phosphorylation. This PKC-mediated phosphorylation can enhance the functional activity of EVI27 if EVI27 is a substrate or is regulated by PKC-dependent pathways. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. The rise in calcium levels can activate calcium-dependent protein kinases, like calmodulin-dependent kinase (CaMK), which potentially phosphorylates EVI27 or its regulatory proteins, leading to an increase in EVI27 activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that acts as a beta-adrenergic agonist. This compound stimulates beta-adrenergic receptors, leading to increased cAMP and subsequent activation of PKA. PKA can then enhance EVI27 activity by phosphorylation or by modulating signaling pathways involving EVI27. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol found in green tea with kinase inhibition properties. It can inhibit certain kinases that negatively regulate EVI27, leading to a reduction in their inhibitory effects and a subsequent increase in EVI27 activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. By activating PKA, db-cAMP may enhance the phosphorylation and activation of EVI27 if EVI27 is part of the PKA-regulated signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases (SAPKs) like JNK. Activation of these kinases can lead to the phosphorylation of regulatory proteins that modulate EVI27 activity, resulting in its functional enhancement. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, this compound can affect downstream signaling pathways, such as Akt. The inhibition of these pathways can remove negative feedback loops and potentially enhance the activity of EVI27 if it is regulated by PI3K/Akt signaling. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that can activate sphingosine-1-phosphate receptors and subsequently modulate cellular signaling pathways. This lipid signaling can lead to the activation of pathways that enhance the activity of EVI27. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases prevents dephosphorylation of proteins, which can lead to an increase in the phosphorylation state of EVI27, enhancing its activity. | ||||||