ETO-2 Activators

Integrin αE activators, in the context of this list, refer to a variety of chemical compounds that, while not directly interacting with Integrin αE, have the potential to influence its activity indirectly. These activators work through different mechanisms, often by modulating signaling pathways or altering the immune response in a way that could affect Integrin αE function.

The first category includes peptides like Arg-Gly-Asp (RGD) peptides, which mimic natural ligands of integrins. By enhancing the binding affinity of integrins to their ligands, these peptides can indirectly influence the activation state of Integrin αE. Another significant group consists of natural compounds such as mangiferin, genistein, curcumin, and epigallocatechin gallate. These compounds are known for their wide-ranging effects on cellular signaling pathways, including those related to immune response and cell adhesion. For instance, curcumin and genistein modulate various signaling molecules and pathways, potentially impacting the activation and function of Integrin αE. Polyphenols like resveratrol and quercetin also play a role in this context. Their ability to interact with multiple molecular targets suggests potential indirect effects on Integrin αE. Similarly, compounds like sulforaphane, piperine, and lycopene, known for their antioxidative and anti-inflammatory properties, could influence Integrin αE activity through their effects on the immune system and cellular stress responses.